The purpose of this study is to evaluate the safety, tolerability and drug levels of BMS-986504 in participants with advanced solid tumors.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
32
Specified dose on specified days
Beijing Cancer hospital
Beijing, Beijing Municipality, China
RECRUITINGFujian Cancer Hospital
Fuzhou, Fujian, China
RECRUITINGMaximum Plasma Concentration (Cmax) of BMS-986504
Time frame: Up to approximately Day 64
Time to Reach Maximum Plasma Concentration (Tmax) of BMS-986504
Time frame: Up to approximately Day 64
Area Under Curve (AUC) of BMS-986504
Time frame: Up to approximately Day 64
Mean Elimination Half-life (T-HALF) of BMS-986504
Time frame: Up to approximately Day 64
Apparent Total Body Clearance (CLT/F) of BMS-986504
Time frame: Up to approximately Day 64
Apparent Volume of Distribution During the Terminal Phase (Vz/F) of BMS-986504
Time frame: Up to approximately Day 64
Number of Participants With Dose-limiting Toxicities (DLTs)
Time frame: Up to approximately Day 25
Number of Participants With Treatment-related Adverse Events (AE)
Time frame: Up to approximately 28 days after last dose of BMS-986504
Number of Participants With all-cause AEs
Time frame: Up to approximately 28 days after last dose of BMS-986504
Number of Participants With Treatment-related Serious AEs (SAEs)
Time frame: Up to approximately 28 days after last dose of BMS-986504
Number of Participants With all-cause SAEs
First line of the email MUST contain the NCT# and Site #.
CONTACT
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Guangdong Provincial People's Hospital
Guangzhou, Guangdong, China
RECRUITINGPeking University Shenzhen Hospital
Shenzhen, Guangdong, China
RECRUITINGLocal Institution - 0006
Harbin, Heilongjiang, China
NOT_YET_RECRUITINGThe First Affiliated Hospital of Xinxiang Medical University
Xinxiang, Henan, China
RECRUITINGShandong Cancer Hospital
Jinan, Shandong, China
RECRUITINGTianjin Medical University Cancer Institute & Hospital
Tianjin, Tianjin Municipality, China
RECRUITINGKanagawa cancer center
Yokohama, Kanagawa, Japan
RECRUITINGShizuoka Cancer Center
Sunto-gun, Shizuoka, Japan
RECRUITING...and 2 more locations
Time frame: Up to approximately 28 days after last dose of BMS-986504
Number of Participants With AEs Leading to Dose Interruption
Time frame: Up to approximately 28 days after last dose of BMS-986504
Number of Participants With AEs Leading to Dose Reduction
Time frame: Up to approximately 28 days after last dose of BMS-986504
Number of Participants With AEs Leading to Treatment Discontinuation
Time frame: Up to approximately 28 days after last dose of BMS-986504
Number of Participants With AEs Leading to Death
Time frame: Up to approximately 28 days after last dose of BMS-986504
Number of Participants With Laboratory Abnormalities
Time frame: Up to approximately 28 days after last dose of BMS-986504