Prophylactic Intravenous Tranexamic Acid on Perioperative Blood Loss in Pregnant Women Undergoing Cesarean Section

Inclusion Criteria: * pregnant women with gestational age 37-42 weeks * undergoing cesarean delivery with indication as follows: placenta previa, severe preeclampsia, myoma uteri, fetal macrosomia, polyhydramnios, grand multiparity ≥ 5 deliveries, prolonged labor, etc. Exclusion Criteria: * history of allergy to tranexamic acid * history of venous thromboembolism (Deep vein thrombosis, Pulmonary embolism) * history of arterial thrombosis (Myocardial infarction, Stroke) * history of seizure, convulsion * have underlying of cardiovascular, renal or liver disease * using of antiplatelet or anticoagulant within 1 week before operation * placenta accreta spectrum * abruptio placenta * Eclampsia or HELLP (Hemolysis Elevated Liver Low Platelet) syndrome * Failed operative vaginal delivery * Multifetal gestation