Efficacy of Corneal Cross-Linking (CXL) in the Treatment of Pediatric Keratoconus

Al-Azhar University20 enrolled

Overview

This prospective interventional study investigates the efficacy of corneal cross-linking (CXL) in managing progressive keratoconus in pediatric patients. The procedure involved standard epithelium-off CXL, and patients were followed to assess outcomes such as visual acuity, keratometric stability, and corneal thickness.

Study Type

INTERVENTIONAL

Allocation

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Keratoconus

Interventions

CrosslinkingPROCEDURE

Corneal Cross-Linking (CXL) is a minimally invasive procedure used to strengthen the cornea by increasing the chemical bonds between collagen fibers. It is primarily used to treat keratoconus and corneal ectasia, conditions where the cornea becomes progressively thinner and weaker.

Eligibility

Sex: ALLMin age: 10 YearsMax age: 20 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Age between 8 and 18 years * Clinical and topographic diagnosis of keratoconus based on the Belin/Ambrosio Enhanced Ectasia Display * Evidence of progression within the past 6-12 months (e.g., an increase in maximum keratometry (Kmax) by ≥1.0 diopter, a decrease in minimal corneal thickness by ≥10 µm, or deterioration in visual acuity not attributable to other causes Exclusion Criteria: * Corneal scarring or opacities. * Active ocular infection or inflammation. * Prior ocular surgery or trauma. * Autoimmune or connective tissue disorders.

Locations (2)

Ehab tharwat

Damietta, New Damietta, Egypt

Al-Azhar university

Damietta, Egypt

Outcomes

Primary Outcomes

keratometry (Kmax)

Kmax (Maximum Keratometry) is the steepest point of curvature on the cornea, and it is a key parameter in diagnosing and monitoring keratoconus.

Time frame: Baseline

keratometry (Kmax)

Kmax (Maximum Keratometry) is the steepest point of curvature on the cornea, and it is a key parameter in diagnosing and monitoring keratoconus.

Time frame: After 12 months

BCVA

Measurment of the visual acuity

Time frame: Baseline

BCVA

Measurment of the visual acuity

Time frame: After 12 months

Data from ClinicalTrials.gov

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