New Saline-contrast EIT Method Without Breath Hold by Low Pass Filter

Peking Union Medical College Hospital22 enrolled

Overview

The electrical impedance tomography (EIT) is a bedside, non-invasive, non-radiation imaging tool for lung mornitoring. Currently, the EIT saline-contrast method for lung perfusion evaluation has been widely used in clinical. However, this technique requires the patient to hold breath for 8-30s to avoid the respiratory interference. Hence, it is not suitable for patients that can not tolerate breath hold or unable to maintain a steady apnoea. This study aims to develop an algorithm system based on low frequency band pass filter for EIT saline-contrast lung perfusion estimation without ventilation interruption, and investigate the correlation and agreement of EIT results between the novel method and the conventional breath-hold method.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

DIAGNOSTIC

Masking

SINGLE

Enrollment

Conditions

Lung Diseases

Interventions

Eligibility

Sex: ALLMin age: 18 YearsMax age: 79 Years

Medical Language ↔ Plain English

Inclusion Criteria: * In need of lung perfusion assessment due to clinical condition * With central venous catheter Exclusion Criteria: * Pregnant or breastfeeding females * contraindications to the use of EIT (automatic implantable cardioverter defibrillator, chest wounds limiting electrode belt placement, implantable pumps, etc.) * severe hyperchloremia (\>155 mmol/L) * unable to tolerate breath-hold maneuver * edema disease (nephrotic syndrome, cirrhotic ascites, congestive heart failure, etc.) * Patients with severe hypernatraemia or hyperchloremia and severe hypertonicity * Hypertension (\>160/100 mmHg), hypokalaemia (\> 3.5 mmol/L) * Acute renal failure in oliguric stage, chronic renal failure with reduced urine output and poor response to diuretics

Outcomes

Primary Outcomes

Regional V/Q match

Time frame: Offline analysis, immediately after the saline injection procedure

Secondary Outcomes

Pixel-wise lung perfusion fraction