JOCOAT Safety and Tolerability Clinical Trial GLAD-04

Pre-operative Inclusion Criteria: * Understand and be able to follow the requirements of the protocol including personally signing and dating an REB approved Informed Consent Form prior to undergoing any protocol related procedures * Subjects aged 15 to 25 years with an ACL-deficient knee undergoing primary ACLR * Subjects with skeletal maturity (i.e. closed epiphyseal growth plates on standard knee radiographs) * At least two of the following factors that are associated with a high risk of graft failure: 1. participate in a competitive pivoting sport (defined as sports that include cutting and pivoting activities such as basketball, American football, soccer, lacrosse, volleyball, tennis/squash, handball, downhill skiing etc); 2. have a pivot shift of grade 2 or greater; 3. have generalized ligamentous laxity (Beighton score of \>= 4) and/or genu recurvatum \> 10 degrees * Biological females have a negative pregnancy test within 4 days of initial surgery * Is willing, able and likely to fully comply with clinical trial procedures and restrictions including follow-ups Pre-operative Exclusion Criteria: * Simultaneous bilateral ACLR * Previous ACLR on either knee * Less than one year from contralateral knee or contralateral/ipsilateral hip/ankle surgery * Prior arthrotomy in the study knee * Active infection anywhere or previous infection in the study knee * History of peri-articular fracture in study knee * \> 3 degrees of asymmetric varus or valgus * The patient has debilitating knee pain that would preclude the use of QT tissue as a graft * The patient has a significant quad tendonitis that would preclude the use of QT tissue as a graft * Known or suspected allergy to brown seaweed, seaweed-based materials such as fucoidan, food allergies and/or presence of any allergy related dietary restrictions unless deemed by the investigator as "Not Clinically Significant" * Known or suspected allergy to fucose, galactose, sulfur, sulfate, sulfite, or any sugar-based polymer or polysaccharides containing these * Known hypersensitivity to sodium lactate or sulfur-containing compounds * Any other severe allergic conditions or previous reactions (e.g., anaphylactic reactions, angioedema) * Severe metabolic acidosis or alkalosis * Have insulin dependent diabetes, severe diabetes and/or poorly controlled diabetes mellitus * Any general medical or surgical condition that would preclude a standard knee ACLR * Inflammatory arthropathy * Breast feeding * Have a medical condition that, in the opinion of the investigator would interfere with the evaluation of the safety or efficacy of the investigational product * Have received any investigational products that, in the opinion of the investigator, would interfere with the evaluation of the safety or efficacy of the investigational product * Have clinically relevant hemochromatosis, hepatic, renal, autoimmune, lymphatic, hematological or coagulation disorders * Family history of blood or coagulation disorders * History of heparin-induced thrombocytopenia (HIT) or known sensitivity to heparin-like products Intra-operative Inclusion Criteria: \- Patient undergoes primary anatomic anterior cruciate ligament reconstruction surgery with quadriceps tendon (QT) graft Intra-operative Exclusion Criteria: * Pre-existing arthrofibrosis in the knee * Partial ACL rupture (defined as one bundle ACL tear requiring reconstruction/ augmentation of the torn bundle with no surgery required for the intact bundle) where ACLR is not performed * Multiple ligament injury (two or more ligaments requiring surgery) * Symptomatic articular cartilage defect requiring treatment other than debridement * Articular cartilage lesion that requires any other surgical treatment apart from debridement * Under anesthetic, this patient has a symmetrical or grade 1 pivot shift AND has a Beighton score \<4 AND \<10 degrees hyperextension