Single implant sites with bone loss can often be managed by bone grafting alone. The purpose of this study is to determine whether putting a soft tissue graft substitute over the bone graft will provide an increased benefit for improving the health, appearance, and stability of the bone and gums surrounding the implant.
The study will treat patients that need a single implant at a previously edentulous site (\>3 months post extraction) that requires phenotypic modification. These patients will receive an implant with simultaneous GBR, with half of the participants also receiving an ADM graft.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
40
Participants will have a dental implant placed at a toothless site
Participants will receive guided bone regeneration at a toothless site with bone substitute and a collagen membrane.
Participants will receive guided bone regeneration at a toothless site with bone substitute and an acellular dermal matrix.
University of Michigan
Ann Arbor, Michigan, United States
RECRUITINGHorizontal linear change of the buccal bone
Radiographic changes of bone level in mm based on cone-beam computed tomography
Time frame: 6 months
The volumetric changes of the facial soft tissue
Volumetric changes in mm\^3 based on intraoral digital scans
Time frame: 6 months
The vascular changes of the facial soft tissue
Vascular changes in mm\^3 based on ultrasound scans
Time frame: 6 months
Peri-implant health, as defined by clinical attachment level.
Changes in clinical attachment level measurements in mm
Time frame: 6 months
Patient-reported morbidity, satisfaction and comfort using a visual analogue scale (VAS)
Difference in survey results
Time frame: 6 months
Clinician-reported overall treatment effectiveness
Scale from 1 (Poor) to 5 (Excellent)
Time frame: 6 months
Histological bone density
Histomorphometry
Time frame: 6 months
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