Reformulated PG324 Ophthalmic Solution for Intraocular Pressure Reduction

Proportion of subjects with moderate to severe conjunctival hyperemia as assessed by biomicroscopy

The subject will undergo a slit lamp examination at all visits, except for dispensing visits. The presence of moderate to severe conjunctival hyperemia (redness) will be recorded.

Time frame: Up to Month 3/study exit

Proportion of subjects with conjunctival hyperemia adverse events

Occurrences of conjunctival hyperemia (redness) adverse events, either subject or investigator reported, will be recorded at each visit.

Time frame: Up to Month 3/study exit

Mean change from diurnally adjusted baseline IOP at each timepoint post-randomization

Intraocular pressure (IOP) will be measured with a Goldmann tonometer and recorded in millimeters mercury (mmHg). IOP will be calculated as the mean of two readings or the median of three readings at each timepoint. Change is defined as the follow-up (Week 2, Week 6, and Month 3) minus baseline (Day 1) at each timepoint.

Time frame: Baseline (Day 1), Week 2, Week 6, Month 3 at 08:00, 10:00, 16:00 hours

Percent change from diurnally adjusted baseline IOP at each timepoint post-randomization

Intraocular pressure (IOP) will be measured with a Goldmann tonometer and recorded in millimeters mercury (mmHg). IOP will be calculated as the mean of two readings or the median of three readings at each timepoint. Change is defined as the follow-up (Week 2, Week 6, and Month 3) minus baseline (Day 1) at each timepoint.