The study aims to phenotype hearing in patients with early stage of neurodegenerative disorders to explore the prevalence of various hearing disorders in comparison to a control population. Specific focus is made on patients with speech-in-noise intelligibiltiy deficit despite normal tonal audiograms referred to as hidden hearing loss, with potential identification of associated biomarkers.
A wide battery of subjective and objective hearing tests is performed on the subjects including tonal and vocal audiometry (in silence and in noise), DPOAE, acoustic reflex and electrophysiology recordings (auditory brainstem response, electrocochleography). Hearing tests are correlated to collected disease parameters and blood markers.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
SCREENING
Masking
NONE
Enrollment
309
Otoscopy Tympanometry Tonal audiometry (air and bone conduction) Vocal audiometry (in silence and in noise) Distorsion Products of OtoAcoustic Emissions (DPOAE) Middle Ear Muscle Reflex (MEMR) Auditory Brainstem Response (ABR) Electrocochleography (EcochG)
CHU Gui de Chauliac
Montpellier, France
RECRUITINGCHU Nice
Nice, France
RECRUITINGCHU Carémeau
Nîmes, France
RECRUITINGPrevalence of hidden hearing loss
Percentage of population in each group that displays normal audiometric thresholds (0.5-4kHz) and impaired speech-in-noise intelligibility
Time frame: within one month from inclusion
Prevalence of sensorineural hearing loss
Percentage of patients in each group with elevated hearing thresholds (0.5-4kHz)
Time frame: within one month from inclusion
Grade of sensorineural hearing loss
As defined by BIAP criteria : \]20-40 dB nHL\] = mild ; \]40 - 55\] = moderate ; \]55 - 70\] = moderately severe ; \]70 - 90\] = severe ; \]90 - 120\] = profound ;
Time frame: within one month from inclusion
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Hospices Civils de Lyon, Hôpital des Charpennes
Villeurbanne, France
RECRUITING