The purpose of this research study is to validate (check the accuracy of) laboratory assays, intravenous catheter insertion, and equipment or devices and their reproducibility, which is necessary to perform high quality research on chronic diseases, nutrition, and metabolism (the process by which a substance is handled in the body) at the University of Missouri. As technology changes and uses new testing methods, it is necessary to compare results from old tests, equipment and devices and new tests, equipment, or devices and the reproducibility of these measurements to make sure the results are accurate. Reproducibility means performing the same test more than once to see if the same results can be achieved each time. This study will look at the validation and reproducibility of tests and laboratory assays in participants who are healthy or affected by relevant endocrine, cardiometabolic, and musculoskeletal disorders.
Study Type
OBSERVATIONAL
Enrollment
100
Participants may opt to have testing performed including blood sampling, urine sampling, intravenous catheter placement with endothelial cell collection, oral glucose tolerance test, consuming a test meal, having imaging performed such as MRI, DEXA, MRS, having adipose (fat) or muscle biopsies, or non-invasive endothelial function testing to investigate use of different assays, different sample treatment approaches to determine optimal conditions that produce the most accurate and reproducible results, and/or repeat testing on different days or with different equipment that measures the same variable.
University of Missouri-Columbia
Columbia, Missouri, United States
RECRUITINGEvaluation of the validity and reproducibility of insulin results in the laboratory environment
Comparison of insulin results across assays (methods of measuring) to evaluate the validity and reproducibility in the basic science laboratory environment across healthy and disordered populations
Time frame: through study completion, up to 6 months
Validation and reproducibility testing for endothelial cell collection
endothelial cell quantity collected
Time frame: through study completion, up to 6 months
Validation and reproducibility testing for mixed meal ingestion
palatability of meal type (protein concentration, carbohydrate concentration) as measured by amount of meal consumed
Time frame: through study completion, up to 6 months
Evaluation of the validity and reproducibility of urinalysis results in the laboratory environment
Comparison of urinalysis results across assays (methods of measuring) to evaluate the validity and reproducibility in the basic science laboratory environment across healthy and disordered populations
Time frame: through study completion, up to 6 months
Validation and reproducibility testing for glucose tolerance testing
glucose levels (mg/dL) at various time points including fasting, random, and postprandial
Time frame: through study completion, up to 6 months
Validation and reproducibility testing for DEXA
body composition analysis (percentage fat and muscle)
Time frame: through study completion, up to 6 months
Validation and reproducibility testing for MRI
body composition analysis (percentage fat and muscle)
Time frame: through study completion, up to 6 months
Validation and reproducibility testing for MRS
body composition analysis (percentage fat and muscle)
Time frame: through study completion, up to 6 months
Validation and reproducibility of vascular (endothelial) function test
non-invasive vascular function test (measured using EndoPat machine)
Time frame: through study completion, up to 6 months
Validation and reproducibility of adipose (fat) tissue biopsy
microscopic characteristics of tissue collected
Time frame: through study completion, up to 6 months
Validation and reproducibility testing of muscle tissue biopsies
microscopic characteristics of tissue collected
Time frame: through study completion, up to 6 months
Evaluation of the validity and reproducibility of C-peptide results in the laboratory environment
Comparison of C-peptide results across assays (methods of measuring) to evaluate the validity and reproducibility in the basic science laboratory environment across healthy and disordered populations
Time frame: through study completion, up to 6 months
Evaluation of the validity and reproducibility of glucagon results in the laboratory environment
Comparison of glucagon results across assays (methods of measuring) to evaluate the validity and reproducibility in the basic science laboratory environment across healthy and disordered populations
Time frame: through study completion, up to 6 months
Evaluation of the validity and reproducibility of free fatty acid level results in the laboratory environment
Comparison of free fatty acid level results across assays (methods of measuring) to evaluate the validity and reproducibility in the basic science laboratory environment across healthy and disordered populations
Time frame: through study completion, up to 6 months
Evaluation of the validity and reproducibility of glucose results in the laboratory environment
Comparison of glucose results across assays (methods of measuring) to evaluate the validity and reproducibility in the basic science laboratory environment across healthy and disordered populations
Time frame: through study completion, up to 6 months
Evaluation of the validity and reproducibility of ketone body results in the laboratory environment
Comparison of ketone body results across assays (methods of measuring) to evaluate the validity and reproducibility in the basic science laboratory environment across healthy and disordered populations
Time frame: through study completion, up to 6 months
Evaluation of the validity and reproducibility of cytokine results in the laboratory environment
Comparison of cytokine results across assays (methods of measuring) to evaluate the validity and reproducibility in the basic science laboratory environment across healthy and disordered populations
Time frame: through study completion, up to 6 months
Evaluation of the validity and reproducibility of adipokine results in the laboratory environment
Comparison of adipokine results across assays (methods of measuring) to evaluate the validity and reproducibility in the basic science laboratory environment across healthy and disordered populations
Time frame: through study completion, up to 6 months
Evaluation of the validity and reproducibility of lipid profile results in the laboratory environment
Comparison of lipid profile results across assays (methods of measuring) to evaluate the validity and reproducibility in the basic science laboratory environment across healthy and disordered populations
Time frame: through study completion, up to 6 months
Evaluation of the validity and reproducibility of urine calcium results in the laboratory environment
Comparison of urine calcium results across assays (methods of measuring) to evaluate the validity and reproducibility in the basic science laboratory environment across healthy and disordered populations
Time frame: through study completion, up to 6 months
Evaluation of the validity and reproducibility of urine magnesium results in the laboratory environment
Comparison of urine magnesium results across assays (methods of measuring) to evaluate the validity and reproducibility in the basic science laboratory environment across healthy and disordered populations
Time frame: through study completion, up to 6 months
Evaluation of the validity and reproducibility of urine phosphorous results in the laboratory environment
Comparison of urine phosphorous results across assays (methods of measuring) to evaluate the validity and reproducibility in the basic science laboratory environment across healthy and disordered populations
Time frame: through study completion, up to 6 months
Evaluation of the validity and reproducibility of urine sodium results in the laboratory environment
Comparison of urine sodium results across assays (methods of measuring) to evaluate the validity and reproducibility in the basic science laboratory environment across healthy and disordered populations
Time frame: through study completion, up to 6 months
Evaluation of the validity and reproducibility of urine oxalate results in the laboratory environment
Comparison of urine oxalate results across assays (methods of measuring) to evaluate the validity and reproducibility in the basic science laboratory environment across healthy and disordered populations
Time frame: through study completion, up to 6 months
Evaluation of the validity and reproducibility of urine citrate results in the laboratory environment
Comparison of urine citrate results across assays (methods of measuring) to evaluate the validity and reproducibility in the basic science laboratory environment across healthy and disordered populations
Time frame: through study completion, up to 6 months
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.