Reduced Intensity Conditioning for MDS

Inclusion Criteria: * Age 14-70 (including boundaries) and gender; * Diagnosis of MDS is confirmed on the basis of bone marrow cytomorphology, immunophenotyping and chromosomal and molecular biology tests; * IPSS-R intermediate-risk or higher-risk or IPSS-M intermediate-risk or higher-risk MDS; transfusion-dependent MDS; * ECOG score≤ 3 points; * Have appropriate organ function, and laboratory results within 7 days prior to the start of trial treatment need to meet the following criteria: * Aspartate aminotransferase (AST) ≤ 3 times ULN (upper limit of normal, ULN); * Alanine aminotransferase (ALT) ≤ 3x ULN; * Total serum bilirubin ≤ 1.5 times the upper limit of normal ULN unless the patient has documented Gilbert syndrome; patients with Gilbert-Meulengracht syndrome with bilirubin ≤ 3.0 times the upper limit of normal and direct bilirubin ≤ 1.5 times the upper limit of normal may be included; * Serum creatinine ≤ 1.5 times ULN or creatinine clearance ≥ 60 mL/min; * Coagulation function: International Normalised Ratio (INR) ≤ 1.5 x ULN, Activated Partial Thromboplastin Time (APTT) ≤ 1.5 x ULN; * Left ventricular ejection fraction (LVEF) ≥50%; * Voluntarily signing the informed consent, understanding and complying with the requirements of the study, good compliance, and cooperating with the follow-up visits. Exclusion Criteria: * Allergies or contraindications to any of the drugs in the protocol; * Currently have clinically significant active cardiovascular disease such as uncontrolled arrhythmias, uncontrolled hypertension, congestive heart failure, any grade 3 or 4 heart disease as determined by the New York Heart Association (NYHA) functional class, or a history of myocardial infarction within the 6 months prior to screening; * Serious medical conditions that may limit the patient's participation in this trial (e.g., progressive infection, uncontrolled diabetes); * Active autoimmune diseases such as SLE, rheumatoid arthritis, etc; * Patients with neurological or psychiatric disorders; * The patient is pregnant or breastfeeding; * Those who are unable to understand or comply with the study protocol or are unable to sign the informed consent form. * Other conditions that, in the opinion of the investigator, make the patient otherwise unsuitable for participation in this study;