This study aimed at comparing the efficacy of nitazoxanide-based triple therapy versus standard triple therapy for eradication of Helicobacter pylori infection in children at a tertiary care hospital.
The findings could guide clinical practice and influence guidelines, improving the management of H. pylori infections in the pediatric population. Not much local data also exists comparing the effectiveness of adding nitazoxanide to the standard triple therapy in children with H. pylori infection. If nitazoxanide-based therapy proves superior, it could reduce the incidence of antibiotic resistance associated with standard triple therapy.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
66
Children were given nitazoxanide, PPI, and clarithromycin for 14 days.
Children received MTZ, PPI, and clarithromycin for 14 days.
Children were given omeprazole for 14 days.
Ziauddin University Hospital
Karachi, Sindh, Pakistan
Treatment efficacy
The patients were considered clinically cured if they had a negative H. pylori stool Ag test and were free of symptoms at 6 weeks after starting treatment, or otherwise failure was labeled.
Time frame: 6 weeks
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Children were given clarithromycin for 14 days.