The Effectiveness of Dexmedetomidine as an Adjuvant for Bupivacaine Caudal Block in Pediatric Open Appendectomy Under General Anesthesia

Ain Shams University60 enrolled

Overview

This study aims to evaluate if adding dexmedetomidine to bupivacaine in a caudal block can provide longer and better quality pain relief for children after open appendectomy surgery. The study will also assess the effect of this combination on the quality of recovery, including the incidence of emergence delirium, and its overall safety profile.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

DOUBLE

Enrollment

Conditions

Appendectomy Pediatric

Interventions

caudal block using dexmedetomidine with bupivacainePROCEDURE

Patients will receive a single-shot caudal block with 1 mL/kg of 0.25% bupivacaine mixed with 1 µg/kg of dexmedetomidine (diluted in 1 mL of normal saline).

caudal block with bupivacainePROCEDURE

Patients will receive a single-shot caudal block with 1 mL/kg of 0.25% bupivacaine mixed with 1 mL of normal saline

Eligibility

Sex: ALLMin age: 2 YearsMax age: 7 Years

Medical Language ↔ Plain English

inclusion criteria: * ASA (American Society of Anesthesiologists) physical status I or II. * Legal guardian provides written informed consent. Exclusion Criteria * Refusal of participation by the legal guardian. * Known allergy or hypersensitivity to local anesthetics or dexmedetomidine. * Coagulation disorder or receiving anticoagulant therapy. * Active infection at or near the injection site. * Significant anatomical abnormalities of the lumbosacral spine. * Pre-existing neurological disorders, psychiatric disorders, or a history of convulsions. * Anticipated surgery time of more than 2.5 hours. * Patients with severe asthma or active wheezing.

Locations (1)

Ain Shams university hospitals

Cairo, Egypt

RECRUITING

Outcomes

Primary Outcomes

Time to First Rescue Analgesia:

Defined as the time interval in minutes from the performance of the caudal block until the first administration of rescue analgesia (ibuprofen), which is prompted by a FLACC pain score of ≥ 4.

Time frame: Up to 24 hours post-caudal block

Data from ClinicalTrials.gov

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