The goal of this clinical study has two objectives. The Primary Objective is to evaluate the effectiveness of microdosed GLP-1 receptor agonists in improving measures of health, quality of life, and longevity. The Secondary Objective: To assess the impact of these therapies on weight management practices and metabolic health.
Participants will be assigned to one of three groups: 1) control, 2) microdosed sublingual semaglutide, 3) microdosed subcutaneous semaglutide. At baseline and every 4 weeks thereafter, participants will be asked to complete surveys on health, wellness, mood, demographic information, and similar. Additionally, at baseline and every 12 weeks thereafter, they will be requested to complete evaluative blood work to measure CBC, CMP, and standard health biomarker panels (e.g., cholesterol, glucose, creatinine, sodium, potassium). From baseline throughout the duration of the study, participants will be given the option to share data from wearable activity and health trackers with the research team for greater accuracy in evaluating measures of activity, sleep, heart rate, and similar.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
150
AgelessRx
Ann Arbor, Michigan, United States
Change in self-reported pain levels in participants microdosing GLP1s
Participants will complete an extensive medical questionnaire every 4 weeks over a 24-week period to monitor self-reported pain levels
Time frame: 6 months
Concentration of complete blood cells, as a measure of immunological health, in participants microdosing GLP1s
CBC panel will be analyzed every 12 weeks over a 24-week period, reported in thousands of cells per microliter with the change from baseline reported as percent deviation and compared to normalized range of healthy individuals
Time frame: 6 months
Concentration of basic metabolites (cholesterol, glucose, creatinine, sodium, potassium), as a measure of immunological health, in participants microdosing GLP1s
BMP panel will be analyzed every 12 weeks over a 24-week period, reported in mg/dL with the change from baseline reported as percent deviation and compared to a normalized range of healthy individuals
Time frame: 6 months
Change in mood in participants microdosing GLP1s
Mood will be assessed every 4 weeks over a 24-week period using the SF-36 standardized questionnaire with deviation reported as percent change from baseline
Time frame: 6 months
Change in heart rate variability in participants microdosing GLP1s
Participants will wear health devices with data monitored every 4 weeks over a 24-week period to observe change in heart rate variability, being defined as the variability of a participant's resting heart rate. Variability will be measured as an average deviation from baseline heart rate at each timepoint and reported as percent difference.
Time frame: 6 months
Changes in sleep patterns in participants microdosing GLP1s
Wearable health device data will be monitored over the 24-week period assessing REM vs non-REM sleep and reported as a ratio
Time frame: 6 months
Change in frequency of physical activity in participants microdosing GLP1s
The change in frequency of physical activity, defined as a departure from baseline in time spent performing moderate to rigorous physical exercise, will be captured via wearable health device data and will be reported as percent difference from baseline in steps taken.
Time frame: 6 months
Change in frequency of physical activity in participants microdosing GLP1s
The change in frequency of physical activity, defined as a departure from baseline in time spent performing moderate to rigorous physical exercise, will be captured via wearable health device data and will be reported as percent difference from baseline in calories burned.
Time frame: 6 months
Variation in concentration of metabolic health biomarkers in participants microdosing GLP1s
Changes in HbA1c levels will be assessed every 12 weeks and reported as a percent deviation from baseline
Time frame: 6 months
Variation in concentration of metabolic health biomarkers in participants microdosing GLP1s
Changes in LDL cholesterol levels will be assessed every 12 weeks and reported as a percent deviation from baseline
Time frame: 6 months
Variation in concentration of metabolic health biomarkers in participants microdosing GLP1s
Changes in HDL cholesterol levels will be assessed every 12 weeks and reported as a percent deviation from baseline
Time frame: 6 months
Variation in concentration of metabolic health biomarkers in participants microdosing GLP1s
Changes in triglyceride levels will be assessed every 12 weeks and reported as a percent deviation from baseline
Time frame: 6 months
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.