Mediation Analysis in Cardiac Surgery

Second Affiliated Hospital, School of Medicine, Zhejiang University13,683 enrolled

Overview

This study investigates the mediating role of intraoperative allogeneic red blood cell transfusion in the relationship between preoperative anaemia and postoperative complications in patients undergoing cardiac surgery. Using mediation analysis methods, we aim to determine whether and to what extent intraoperative transfusion explains the association between preoperative anaemia and adverse postoperative outcomes. By elucidating this pathway, the study seeks to inform perioperative blood management strategies and support more personalized, risk-adapted approaches to minimize postoperative complications in anaemic patients undergoing cardiac procedures.

Study Type

OBSERVATIONAL

Enrollment

13,683

Conditions

Anemia Cardiac Surgery Transfusion Mediation

Interventions

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Adults aged 18 and older ； * Undergoing elective cardiac surgery with cardiopulmonary bypass Exclusion Criteria: * preoperative mechanical circulatory support * ASA physical status VI-V * unplanned intra-hospital reoperations * catheter-based valve replacements, * heart tumours, * stent implantation surgeries, * coronary angiography, * transvascular valve clamping, * tetralogy of Fallot, * ventricular aneurysms, * cardiomyopathies,

Locations (1)

Department of Anesthesiology, Second Affiliated Hospital, Zhejiang University School of Medicine

Hangzhou, Zhejiang, China

Outcomes

Primary Outcomes

Incidence of Postoperative Complications

The primary outcome is the occurrence of any postoperative complications during the index hospitalization. Complications include, but are not limited to, acute kidney injury (AKI), neurological complications, infections, and pulmonary complications. These are assessed using standardized diagnostic criteria.