Study on the Recovery of Visual Perceptual Function Dysfunction in Patients With Diabetes

The First Affiliated Hospital of Anhui Medical University36 enrolled

Overview

Investigators aim to investigate the effectiveness of visual perceptual learning on visual perceptual function in participants with diabetic retinopathy and to provide novel therapeutic insights for visual functional rehabilitation in diabetic retinopathy.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Enrollment

Conditions

Diabetic Retinopathy (DR)Visual Perception

Interventions

visual perceptual learningPROCEDURE

Participants in the VPL group performed 40 minutes of daily monocular training at home for three months, with follow-up evaluations conducted at 1 month and 3 months after training initiation.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 65 Years

Medical Language ↔ Plain English

Inclusion Criteria: * moderate to severe non-proliferative diabetic retinopathy (NPDR) and proliferative diabetic retinopathy(PDR) prior to treatment(17) * prior pan retinal laser photocoagulation (PRP) at least 4 weeks before enrollment or vitreoretinal surgery at least 8 weeks before enrollment * stable clinical condition * best-corrected visual acuity (BCVA) \> 1.0 logMAR (equivalent to a Snellen visual acuity of \< 20/200) * clear refractive media * age ≤ 65 years * ability to comprehend the examination and training procedures Exclusion Criteria: * significant refractive media opacity * psychiatric disorders, chronic alcoholism and traumatic brain injury * new-onset vitreous hemorrhage, myopia, strabismus, amblyopia, glaucoma and macular diseases.

Locations (1)

The First Affiliated Hospital of Anhui Medical University

Hefei, Anhui, China

Outcomes

Primary Outcomes

contrast sensitivity

The contrast sensitivity measurements include grating acuity, first-order motion stimulus perception sensitivity, second-order stationary stimulus perception sensitivity and second-order motion stimulus perception sensitivity, which represent the reciprocal of the contrast threshold.

Time frame: From enrollment to the end of treatment at 12 weeks

Secondary Outcomes

The Low Vision Quality of Life Questionnaire

This instrument has demonstrated high reliability and validity, and is sensitive to changes in visual function among individuals with vision loss. The minimum value is 25 and the maximum value is 125. Higher scores indicate better quality of life.

Time frame: From enrollment to the end of treatment at 12 weeks

Data from ClinicalTrials.gov

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