Background: Immediate implants provide ideal three-dimensional positioning compared to conventional implants. There may be a gap between the surface of the implant and the bone walls of the socket when it is inserted into a recently extracted alveolus. To compensate for this, various grafting materials are used. Recently, melatonin has gained significant attention because of its inhibitory action on bone resorption through upregulating the expression of osteoprotegerin, which acts as a decoy receptor for RANKL and inhibits its binding to osteoclast precursors thereby inhibiting osteoclast formation and activity. So, we will conduct this study to evaluate the effects of local melatonin application around immediately placed implants. Aim of the study: To evaluate the effectiveness of adding local melatonin around immediately placed implants in maxillary premolars.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
24
Patients will receive immediately placed implants with local melatonin powder (3mg) application.
Patients will receive immediately placed implants without local melatonin application.
Outpatient Clinic of Oral and Maxillofacial Surgery Department, Faculty of Dentistry, Alexandria University
Alexandria, Egypt
Change in Osteoprotegerin
OPG (Ng/ml) level will be measured preoperatively, 1 and 3 months post operatively, to evaluate the bone healing activity. The level will be evaluated by collecting 5 ml of peripheral blood in blank tubes and will be allowed for complete clotting and will be centrifuged at 1000 g for 15 min. The separated serum will be then stored at -20 0C.
Time frame: Baseline, 1 month, and 3 months
Change in bone volume
CBCT scans will be obtained to measure change in bone volume
Time frame: Baseline and 6 months
Change in bone level
CBCT scans will be obtained to measure change in bone level
Time frame: Baseline and 6 months
Change in bone density
CBCT scans will be obtained to measure change in bone density
Time frame: Baseline and 6 months
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