The Nonirritating Concentrations of Midazolam, Ketamine, and Ondansetron

Mayo Clinic21 enrolled

Overview

Perioperative anaphylaxis is a potentially life-threatening drug allergic reaction that can occur during anesthetic procedures. The purpose of this research is to determine the maximal nonirritating skin testing concentrations of midazolam, ketamine and ondansetron. These drugs are FDA approved and commonly used before, during and after surgical procedures.

Study Type

INTERVENTIONAL

Allocation

Purpose

DIAGNOSTIC

Masking

NONE

Enrollment

Conditions

Allergy

Interventions

Skin TestingDIAGNOSTIC_TEST

Participants will undergo skin prick testing and intradermal test injections at 5 increasing concentrations of midazolam, ketamine and/or ondansetron during one single study visit.

Eligibility

Sex: ALLMin age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Not have a history of an adverse reactions to midazolam, ketamine or ondansetron * Ability to understand study procedures and to comply with them for the entire length of the study. * Contraception is not necessary, and we will include women of reproductive capability. Exclusion Criteria: * Unstable patients. * History of any adverse reaction (allergy or sensitivity) to midazolam, ketamine or ondansetron. * Pregnant and Pediatric patients * Inability or unwillingness of individual or legal guardian/representative to give written informed consent.

Locations (1)

Mayo Clinic Arizona

Scottsdale, Arizona, United States

Outcomes

Primary Outcomes

Nonirritating Concentrations of Midazolam, Ketamine, and Ondansetron.

Determine the maximal nonirritating concentrations of midazolam, ketamine and ondansetron

Time frame: 1 Day

Secondary Outcomes

Skin Testing Results

Determine the frequency of false positive test results in patients who have received Midazolam, Ketamine or Ondansetron in the past.

Time frame: 1 Day

Data from ClinicalTrials.gov

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