Non-invasive Diffusion-weighted Imaging With MRCP in the Diagnosis of Neoplastic Biliary Obstruction

The General Authority for Teaching Hospitals and Institutes100 enrolled

Overview

This study aims to evaluate the diagnostic value of non-invasive diffusion-weighted magnetic resonance imaging (DW-MRI) in detecting neoplastic biliary obstruction.

Both surgeons and endoscopists value accurate approaches for identifying the source of biliary stricture in patients with obstructive jaundice. Cholangiocarcinoma or a benign stricture may cause a biliary stricture. Many imaging methods were used to diagnose the cause of biliary stricture. Diffusion-weighted magnetic resonance imaging (DW-MRI) has emerged as a non-invasive imaging modality that can potentially differentiate between malignant and benign biliary obstructions based on the measurement of water diffusion in tissues. The gold standard of the research is endoscopic retrograde cholangiopancreatography (ERCP) and histology. Patients' diagnoses and follow-up were further verified by ERCP or histopathology.

Study Type

OBSERVATIONAL

Enrollment

100

Conditions

Non-invasive Diffusion-weighted Imaging Magnetic Resonance Cholangiopancreatography Diagnosis Neoplastic Biliary Obstruction

Interventions

Magnetic Resonance CholangiopancreatographyOTHER

Patients who are scheduled for magnetic resonance cholangiopancreatography and have undergone conventional imaging

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Adult patients (≥18 years) with clinically suspected biliary obstruction (e.g., jaundice, elevated liver enzymes, cholestasis). * Patients who are scheduled for magnetic resonance cholangiopancreatography (MRCP) and have undergone conventional imaging \[ultrasound or computed tomography (CT)\]. * Patients who will undergo further invasive procedures, e.g., endoscopic retrograde cholangiopancreatography (ERCP), biopsy. Exclusion Criteria: * Patients with contraindications to magnetic resonance imaging (MRI) (e.g., pacemakers, metal implants). * Patients who have previously undergone major biliary surgery or stent placement. * Pregnant or lactating women.

Locations (1)

General Authority for Teaching Hospitals and Institutes

Cairo, Egypt

RECRUITING

Outcomes

Primary Outcomes

Sensitivity of magnetic resonance cholangiopancreatography

Sensitivity of magnetic resonance cholangiopancreatography to predict of a tumor will be recorded.

Time frame: Immediately after magnetic resonance cholangiopancreatography (Up to 1 hour)

Central Contacts

Hekmat S Baumey, MD

CONTACT

00201555433546 hekmattsamir@gmail.com

Data from ClinicalTrials.gov

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