Bovine Bone With or Without Concentrated Growth Factor in the Treatment of Chronic Periodontitis

Tanta University20 enrolled

Overview

The aim of this study is to compare bovine bone with or without concentrated growth factor in the treatment of chronic periodontitis.

Periodontitis is an infection-driven inflammatory disease resulting from dental plaque accumulation at the gingival margin, triggering an inflammatory response that leads to microbial alterations and may have severe consequences for the periodontium of susceptible individuals. The xenograft most commonly used in periodontal regeneration procedures is the deproteinized bovine or equine bone mineral. Platelets are known to play a significant role in guided tissue regeneration (GTR) by releasing several growth factors, such as platelet-derived growth factor (PDGF), and plasma rich in growth factors (PRGF), which are present in platelet-rich plasma (PRP), a first-generation platelet concentrate. Platelet-rich fibrin (PRF) and concentrated growth factors (CGF) are considered the second generation of platelet concentrate.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Bovine Bone Concentrated Growth Factor Chronic Periodontitis

Interventions

Concentrated growth factors, collagen membrane and xenograft bone graftOTHER

Ten sites were treated by concentrated growth factors (CGF), collagen membrane, and xenograft bone graft.

Collagen membrane and xenograft bone graftOTHER

Ten sites were treated with a collagen membrane and a xenograft bone graft.

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Presence of angular periodontal intra-bony defects with a pocket depth (PD) ≥ 5mm. * Optimal compliance as evidenced by no missed treatment appointments and a positive attitude towards oral hygiene. * Full-mouth bleeding score ≤ 25%. Exclusion Criteria: * Patients with relevant medical conditions that may affect periodontal regeneration and periodontal surgery. * Patients who have any disease or take any medication that affects the normal number or function of platelets. * Smokers. * Pregnant or lactating women. * Patients in whom periodontal surgery had previously been carried out on the selected site. * Patients with aggressive periodontitis.

Locations (1)

Tanta University

Tanta, El-Gharbia, Egypt

Outcomes

Primary Outcomes

Probing Pocket depth

Probing Pocket depth (PPD) was measured.

Time frame: 6 months post-procedure

Secondary Outcomes

Clinical attachment level

Clinical attachment level (CAL) was measured.

Time frame: 6 months post-procedure

Bleeding on probing

Bleeding on probing (BOP) was measured.

Time frame: 6 months post-procedure

Plaque index

Plaque index (PI) was measured.

Time frame: 6 months post-procedure

Data from ClinicalTrials.gov

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