This is a multi-cohort, multi-center Phase II clinical study exploring the efficacy of treatment with either Adebrelimab plus SHR-A1811/SHR-A1904 and chemotherapy, or Adebrelimab plus SHR-8068 in patients with gastric or gastroesophageal junction (GEJ) cancer. The study also evaluates the safety and tolerability of these combination regimens.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
200
Adebrelimab injection.
SHR-A1811 for injection.
SHR-A1904 for injection.
SHR-8068 injection.
The Fourth Hospital of Hebei Medical University
Shijiazhuang, Hebei, China
RECRUITINGZhejiang Cancer Hospital
Hangzhou, Zhejiang, China
RECRUITINGPathological complete response (pCR) rate assessed by the Pathology Review Committee (PRC).
Time frame: Approximately 13 weeks.
Incidence and severity of adverse events (AEs) evaluated per NCI-CTCAE v5.0.
Time frame: Approximately 1 year.
Incidence and severity of serious adverse events (SAEs) evaluated per NCI-CTCAE v5.0.
Time frame: Approximately 1 year.
Major pathological response (MPR) rate assessed by the Pathology Review Committee (PRC).
Time frame: Approximately 13 weeks.
Pathological complete response (pCR) rate evaluated by the investigational site's pathology assessment.
Time frame: Approximately 13 weeks.
Event-Free Survival (EFS).
Time frame: Approximately 1 year.
Disease-Free Survival (DFS).
Time frame: Approximately 1 year.
Objective Response Rate (ORR).
Time frame: Approximately 1 year.
Overall Survival (OS).
Time frame: Approximately 2 years.
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.