Pediatric Intravenous Contrast-Enhanced Ultrasound(CEUS) in China

The Children's Hospital of Zhejiang University School of Medicine108 enrolled

Overview

The goal of this clinical trial is to evaluate the application of intravenous contrast-enhanced ultrasound examination in children with intra-abdominal diseases that require clear diagnoses. The main questions it aims to answer are: * Is intravenous contrast-enhanced ultrasound helpful for the diagnosis of intra-abdominal diseases in children? * What medical problems do participants have when participating in intravenous contrast-enhanced ultrasound examination? * How can ultrasound doctors conduct intravenous contrast-enhanced ultrasound examinations in a standardized manner? Researchers will performing intravenous contrast-enhanced ultrasound examinations on participants and collecting research subjects to establish a multicenter clinical data database. Participants will: * Perform abdominal ultrasound examination to assess the condition. * At least conduct one intravenous contrast-enhanced ultrasound examination. Based on the result of the contrast examination, decide whether to conduct another examination. * Keep a diary of their symptoms and therapeutic process in 30 days.

Study Type

OBSERVATIONAL

Enrollment

108

Conditions

Abdominal Neoplasm Abdominal Injury Ascites

Interventions

Eligibility

Sex: ALLMin age: 29 DaysMax age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: 1. Age 29 days to 18 years old; 2. The clinical diagnosis was abdominal space-occupying lesions, blunt abdominal trauma, ascites of unknown cause, and children with suspected abdominal disease but other examinations could not identify the cause. Exclusion Criteria: 1. Allergic to sulfur hexafluoride or other components; 2. Heart disease with right-to-left shunt/severe pulmonary hypertension /uncontrolled systemic hypertension/respiratory failure/heart failure/severe arrhythmia; 3. Electrocardiogram, echocardiography or clinical manifestations of myocardial ischemia; 4. Patients with severe blood system diseases or infectious diseases; 5. Hypercoagulable state and recent history of thrombosis; 6. Severe hepatic and renal insufficiency; 7. Patients with respiratory tract infection or congenital respiratory malformation.

Outcomes

Primary Outcomes

sensitivity

to calculate the sensitivity of venous contrast-enhanced ultrasound examination in children

Time frame: Thirty days after the last venous ultrasound contrast examination

specificity

to calculate the specificity of venous contrast-enhanced ultrasound examination in children

Time frame: Thirty days after the last venous ultrasound contrast examination

Positive predictive value

to calculate the positive predictive value of venous contrast-enhanced ultrasound examination in children

Time frame: Thirty days after the last venous ultrasound contrast examination

Negative predictive value

to calculate the negative predictive value of venous contrast-enhanced ultrasound examination in children

Time frame: Thirty days after the last venous ultrasound contrast examination

Pediatric Intravenous Contrast-Enhanced Ultrasound(CEUS) in China

Overview

Conditions

Interventions

Eligibility

Locations (1)

Outcomes

Primary Outcomes

Central Contacts