The actual role of POLE mutations in high-risk endometrial cancer is undetermined. The main question it aims to answer is: What is the prevalence of POLE mutations in high-risk endometrial cancer case? What is the impact of POLE mutations in real world high-risk endometrial cancer case?
All high-risk recurrent endometrial cancer cases who were treated in a tertiary referral center will be analyzed and subjected to POLE mutation analysis. In addition, survival analysis will be used to analyze the role of POLE mutations in women with high-risk endometrial cancer. We can answers the following. 1. What is the prevalence of POLE mutations in women with high-risk endometrial cancer? 2. What is the role of POLE mutations in real world high-risk endometrial cancer?
Study Type
OBSERVATIONAL
Enrollment
150
Department of Obstetrics and Gynecology, Far Eastern Memorial Hospital
Banqiao District, New Taipei, Taiwan
RECRUITINGPrevalence of POLE mutation in high risk endometrial cancer
The prevalence of POLE mutations in women with high-risk for recurrent endometrial cancer
Time frame: 2 years
The impact of POLE on overall survival
The impact of POLE on overall survival, compared with the other TCGA groups
Time frame: 5 years
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