This study aims to establish a personalized theta burst stimulation (TBS, an advanced variant of repetitive transcranial magnetic stimulation, rTMS) protocol considering autistic idiosyncrasy (interindividual variability).
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Enrollment
60
Participants will receive a single session of either iTBS or cTBS (600 pulses) targeting the right cerebellar Crus I/II. One week after the initial TBS, they will receive another single session of iTBS or cTBS (600 pulses) at the same site.
Chang Gung Memorial Hospital
Taoyuan, Taiwan
RECRUITINGFunctional MRI (default mode network) - BOLD Signal
Blood-oxygen-level-dependent (BOLD) signal is a measurement used in fMRI, which reflects the neural activity.
Time frame: Baseline, Week 1, Week 2
MEP amplitude
MEP (motor evoked potential) amplitude is a measure of corticospinal excitability.
Time frame: Baseline
MEP amplitude
MEP (motor evoked potential) amplitude is a measure of corticospinal excitability.
Time frame: Week 1 (5 minutes post-TBS)
MEP amplitude
MEP (motor evoked potential) amplitude is a measure of corticospinal excitability.
Time frame: Week 2 (5 minutes post-TBS)
MEP amplitude
MEP (motor evoked potential) amplitude is a measure of corticospinal excitability.
Time frame: Week 1 (10 minutes post-TBS)
MEP amplitude
MEP (motor evoked potential) amplitude is a measure of corticospinal excitability.
Time frame: Week 2 (10 minutes post-TBS)
MEP amplitude
MEP (motor evoked potential) amplitude is a measure of corticospinal excitability.
Time frame: Week 1 (15 minutes post-TBS)
MEP amplitude
MEP (motor evoked potential) amplitude is a measure of corticospinal excitability.
Time frame: Week 2 (15 minutes post-TBS)
MEP amplitude
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MEP (motor evoked potential) amplitude is a measure of corticospinal excitability.
Time frame: Week 1 (20 minutes post-TBS)
MEP amplitude
MEP (motor evoked potential) amplitude is a measure of corticospinal excitability.
Time frame: Week 2 (20 minutes post-TBS)