This study aims to compare central sensitization parameters between carpal tunnel syndrome (CTS) patients with extra median symptom distribution and those with typical, median nerve-related symptoms. Extra median sensory spread, observed in some CTS patients beyond the anatomical boundaries of the median nerve, may reflect central sensitization mechanisms. Using the Central Sensitization Inventory and pressure pain threshold measurements, this study will assess whether extra median symptom patterns are associated with increased central sensitization.
Carpal Tunnel Syndrome (CTS) is the most common entrapment neuropathy, typically presenting with numbness and tingling in the thumb, index, and middle fingers due to median nerve compression at the wrist. However, some patients report symptom spread beyond the median nerve distribution, involving ulnar regions of the hand, forearm, shoulder, or even scapular areas. This phenomenon, known as extra median symptom distribution, has been increasingly associated with central sensitization (CS).This study aims to compare central sensitization parameters between CTS patients with typical symptoms and those showing extra median spread. Pressure pain threshold (PPT) and Central Sensitization Inventory (CSI) scores will be used to evaluate sensitization levels. The initial hypothesis of this study was that patients with extra-median symptoms would exhibit lower PPT values and higher CSI scores, indicating greater central sensitivity. Findings may highlight the need to consider central mechanisms in CTS management and promote more personalized treatment approaches.
Study Type
OBSERVATIONAL
Enrollment
80
Ultrasonographic evaluation of the median nerve at the carpal tunnel and adjacent levels
Upper extremity nerve conduction studies including median-ulnar sensory and motor responses
Pain pressure threshold is used to measure deep muscular tissue pain sensitivity.
Sultan Abdülhamid Han Training and Research Hospital
Istanbul, Usküdar, Turkey (Türkiye)
RECRUITINGPressure pain threshold
Pain pressure threshold (PPT) is used to measure deep muscular tissue sensitivity. Algometer is used in the measurement and low values are interpreted in favor of increased sensitivity.
Time frame: 3 months
Katz hand diagram
The Katz Hand Diagram is a self-reported symptom map used to support the diagnosis of Carpal Tunnel Syndrome (CTS). Patients are asked to mark areas on a standardized hand diagram where they experience pain, numbness, or tingling. This tool helps clinicians assess whether symptoms follow a median nerve distribution and is commonly used in both clinical and research settings due to its simplicity and diagnostic value.
Time frame: 3 months
Central sensitization inventory (CSI)
Clinical instrument used in the diagnosis of central sensitization. A CSI part-A score of 40 and above is significant in the diagnosis. The score range is between 0 and 100, and as the score increases, the severity of sensitization symptoms increases.
Time frame: 3 months
Visual analog scale
The visual analog scale (VAS) is a validated subjective measure for pain, scored in the 0-10 range (0:no pain; 10: worst pain).
Time frame: 3 months
hand grip strength
Grip strength is a measure of muscle strength or the maximum force/tension produced by one's forearm muscles and is measured with a hand dynamometer.
Time frame: 3 months
Median nerve conduction studies-latency measurement
Latency values obtained in bilateral median motor and sensory nerve conduction studies.
Time frame: 3 months
Median nerve motor conduction studies-amplitude measurement
Amplitude values obtained in bilateral median motor nerve conduction studies.
Time frame: 3 months
Median nerve sensory conduction studies-amplitude measurement
Amplitude values obtained in bilateral median sensory nerve conduction studies.
Time frame: 3 months
Median nerve conduction studies- conduction velocity measurement
Conduction velocity values obtained in bilateral median motor and sensory nerve conduction studies.
Time frame: 3 months
Median nerve ultrasound cross-sectional area measurement
Median nerve cross-sectional area and echogenicity measurement
Time frame: 3 months
Median nerve ultrasound echogenicity measurement
Median nerve echogenicity measurement
Time frame: 3 months
Short form-12
The 12-item Short Form Questionnaire (SF-12) is used for objective measurement of quality of life. The SF-12 provides two norm-based summary scores-Physical (PCS) and Mental (MCS)-each ranging from 0 to 100. Higher scores indicate better health, with 50 as the average based on U.S. norms.
Time frame: 3 months
Self Leeds Assessment of Neuropathic Symptoms and Sign (S-LANSS)
S-LANSS is a 7-question scale used to define pain of neuropathic origin. The score range is between 0-24 and a score of 12 points or more is in favor of the presence of neuropathic pain.
Time frame: 3 months
Boston Carpal Tunnel Questionnaire (BCTQ)
The Boston Carpal Tunnel Questionnaire (BCTQ) includes two subscales: the Symptom Severity Scale (SSS) and the Functional Status Scale (FSS). The SSS consists of 11 items, each scored from 1 (no symptoms) to 5 (very severe symptoms), resulting in a total score range of 11 to 55 and an average score range of 1.0 to 5.0. The FSS contains 8 items, also scored from 1 (no difficulty) to 5 (unable to perform), yielding a total score range of 8 to 40 and an average score range of 1.0 to 5.0. Higher scores on both subscales indicate greater symptom severity or functional limitation.
Time frame: 3 months
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