EEG Measurements to Capture DBS-induced Electric Potentials

Universitätsklinikum Hamburg-Eppendorf20 enrolled

Overview

To measure the electric fields induced by DBS (deep brain stimulation) on the scalp and to improve electric field simulations, the investigators will measure EEG (electroencephalography) measurements with high sampling rates (\>100 kHz). The investigators hypothesize that we can improve electric field simulations of DBS by validating and calibrating the simulations based on EEG measurements at high sampling rates (\>100 kHz).

Study Type

OBSERVATIONAL

Enrollment

Conditions

Deep Brain Stimulation Parkinson's Disease

Interventions

EEG recordingOTHER

EEG will be recorded at high sampling rate

Eligibility

Sex: ALLMin age: 35 YearsMax age: 85 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Provision of written informed consent by the patient * Age 35 - 85 * patient groups: Parkinson's disease, essential tremor, dystonia * \>3 months after surgery for DBS Exclusion Criteria: none.

Locations (1)

University Medical Center Hamburg-Eppendorf

Hamburg, Germany

RECRUITING

Outcomes

Primary Outcomes

Electric potential at the EEG locations

The investigators will extract the DBS pulses from the EEG data and check the distribution of the electric potentials as seen in simulations based on individual MRI and CT images. Parameters of the simulation pipeline (e.g. conductances) will be adjusted so that the simulation models fit the data.

Time frame: during DBS

Central Contacts

Bettina C. Schwab, PhD

CONTACT

+49 40 7410 26907 b.schwab@uke.de

Thomas Keizers

CONTACT

t.keizers@utwente.nl

Data from ClinicalTrials.gov

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