The aim of the project is to elucidate the impact of diverse sex hormone profiles on the adaptability of muscle mass to physical training. Additionally, the project aims to investigate secondary effects on adipose tissue, tendons, and other physiological parameters associated with physical function.
The human study is designed as a prospective study where 3 groups with different sex hormonal profiles are followed in parallel in 4 months and tested before, during (2 months) and after 4 months of physical training intervention. The three groups include a control group with regular menstrual bleeding and two groups who have an altered sex hormonal profile due to use of either IUD (containing the progestin levonorgestrel) or mini pills (containing the progestin desogestrel). Before and after the training period the following will be measured/collected: Body composition, Dietary intake, Physical Activity Level, Blood, Urine, Muscle Tissue, Adipose Tissue, Aerobic capacity in bike test, Strength and muscle function tests, and questionnaires about diet and physical activity.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Enrollment
60
Aerobic and resistance training three times per week. Two supervised training sessions.
Muscle mass
Muscle mass measured by DXA
Time frame: 4 months
Fat free mass
Fat free mass measured by DXA
Time frame: 4 months
Muscle fiber
Muscle fiber type and area
Time frame: 4
Protein synthesis and degradation
Muscle protein synthesis and degradation
Time frame: 4 months
Adipose tissue sex hormone receptors
Adipose tissue sex hormone receptors
Time frame: 4 months
Resting metabolic rate
Resting metabolic rate measured via indirect calorimetry
Time frame: 4 months
Maximal oxygen uptake
Maximal oxygen uptake
Time frame: 4 months
Muscle strength
Muscle strength (arm and finger strength)
Time frame: 4 months
Appetite regulatory markers
Leptin, Ghrelin, CCK, GLP-1
Time frame: 4 months
Lipid profile
Lipid profile
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.
Time frame: 4 months