Imaging Markers of High-Risk Plaque Phenotype for Predicting Post-PCI Outcomes

N/AActive Not RecruitingNCT07117084

Chinese Academy of Medical Sciences, Fuwai Hospital2,000 enrolled

Overview

Despite the widespread use of stents, previous studies have shown that stent implantation mainly relieves symptoms but may not significantly improve long-term outcomes in patients with stable coronary artery disease. Identifying the types of plaques that are most likely to benefit from stenting is essential for improving personalized treatment. This study explores whether coronary computed tomography angiography (CCTA)-derived imaging biomarkers of coronary plaques are associated with increased risk of adverse outcomes after percutaneous coronary intervention (PCI). Around 2,000 patients who underwent CCTA followed by stent placement were included. Advanced software was used to quantify plaque inflammation and composition. Findings from this research may help guide personalized treatment strategies in patients undergoing PCI.

Study Type

OBSERVATIONAL

Enrollment

2,000

Conditions

Coronary Artery Disease Percutaneous Coronary Intervention (PCI)Atherosclerosis of Coronary Artery

Interventions

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: 1. patients aged 18 years or older; 2. patients who underwent clinically indicated PCI within 30 days following CCTA; 3. CCTA demonstrating the presence of coronary atherosclerotic plaque. Exclusion Criteria: 1. patients whose PCI within 30 days after CCTA was performed on an emergency basis; 2. elevated cardiac troponin levels within the 3 months preceding PCI; 3. inadequate CCTA image quality; 4. balloon-only or mixed stent/balloon PCI strategies; 5. PCI for non-atherosclerotic lesions (e.g., in-stent restenosis, spontaneous coronary dissection); 6. history of coronary artery bypass grafting; 7. heart failure; 8. non-ischemic cardiomyopathy; 9. significant valvular heart disease; 10. refractory hypertension; 11. persistent atrial fibrillation.

Locations (3)

Fuwai Hospital, Chinese Academy of Medical Sciences

Beijing, Beijing Municipality, China

Tai'an Central Hospital

Tai’an, Shandong, China

Weifang People's Hospital

Weifang, Shandong, China

Outcomes

Primary Outcomes

Major adverse cardiovascular events (MACE)

Composite of cardiovascular death, non-fatal myocardial infarction, repeat revascularization, and hospitalization for unstable angina.

Time frame: From the date of PCI until December 2024 (minimum 2-year follow-up)