To observe the effects of remimazolam versus ciprofol TIVA on PRAE in pediatric tonsillectomy and adenoidectomy.
To observe the effects of remimazolam versus ciprofol TIVA on PRAE in pediatric tonsillectomy and adenoidectomy, aiming to enhance surgical safety and improve postoperative outcomes in pediatric patients.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
DOUBLE
Enrollment
114
remimazolam induction (0.3-0.5 mg/kg) + maintenance (1-3 mg/kg/h)
Anesthesia induction (2-3 mg/kg) + Anesthesia maintenance (6-10 mg/kg/h)
Anesthesia induction (0.4-0.5 mg/kg) + Anesthesia maintenance (0.8-1.2 mg/kg/h)
Tongji Hospital
Wuhan, Hubei, China
RECRUITINGThe incidence of perioperative respiratory adverse events
The perioperative respiratory adverse events including: laryngospasm, bronchospasm, severe cough, oxygen desaturation, airway obstruction.
Time frame: 5days
Anesthesia duration
From anesthesia induction to discontinuation of anesthetics
Time frame: 1 day
Emergence time
From anesthetic discontinuation to eye opening on command
Time frame: 1 day
Extubation time
From anesthetic discontinuation to endotracheal tube removal
Time frame: 1 day
PACU stay duration
From PACU admission to meeting discharge criteria
Time frame: 1 day
The modified Aldrete score
Upon admission to the PACU, the child was assessed using the modified Aldrete score, which ranges from 0 to 10. A higher score indicates a better recovery status.
Time frame: 1 day
doses of drugs
Total sedative/analgesic consumption
Time frame: 24 hours
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