High Dose Eylea for Proliferative Diabetic Retinopathy Outcomes

Inclusion Criteria: * Willing and able to comply with clinic visits and study-related procedures * Provide signed informed consent * Men or women \> 18 years of age at the time of signing the Informed Consent Form * Diagnosed with type 1 or type 2 diabetes mellitus * BCVA ETDRS \>/= 20/400 in the study eye * Proliferative Diabetic Retinopathy as diagnosed via clinical examination and fluorescein angiography Exclusion Criteria: * Any known hypersensitivity to any of the components of aflibercept 8 mg injection * Any known hypersensitivity to any contrast media (e.g., fluorescein), dilating eye drops, disinfectants (e.g., iodine), or any of the anesthetics and antimicrobial preparations used bye the site during the study * Prior systemic anti-VEGF or IVT anti-VEGF treatment in the study eye within 3 months of enrollment. (i.e., 3-month wash-out period for anti-VEGF allowed) * Any intra- or periocular corticosteroid treatment in the study eye within 3 months of baseline * Any intraocular sustained-release treatment or implantable device * Any gene therapy in the study eye * SD-OCT central subfield thickness measurement of \> 320 µm, in the study eye * Evidence of ocular infection, in the study eye, at time of screening * IOP \> 25 mmHg in the study eye * Any intraocular inflammation/ infection in either eye within 12 weeks (84 days) of the screening visit * History of vitreoretinal surgery in the study eye * Any prior Panretinal laser photocoagulation (PRP) in the study eye * Current vitreous hemorrhage obscuring clear view of the macula in the study eye * Presence of tractional retinal detachment and/or pre-retinal fibrosis causing retinal elevation/ thickening * Cataract surgery in the study eye within 4 weeks prior to Screening/ Day 0 * Blood pressure \> 180/100 mmHg systolic/ diastolic, while seated * Pregnant or breastfeeding women * Sexually active men\* or women of childbearing potential\*\* who are unwilling to practice adequate contraception during the study (adequate contraceptive measures include stable use of oral contraceptives or other prescription pharmaceutical contraceptives for 2 or more menstrual cycles prior to screening/ baseline; intrauterine device \[IUD\]; bilateral tubal ligation; vasectomy; condom plus contraceptive sponge, foam, or jelly, or diaphragm plus contraceptive sponge, foam, or jelly). * Contraception is not required for men with documented vasectomy * Postmenopausal women must be amenorrhoeic for at least 12 months in order not to be considered of childbearing potential. Pregnancy testing and contraception are not required for women with documented hysterectomy or tubal ligation.