Menopausal Impact on Skin Aging Among Egyptian Women

N/ANot Yet RecruitingNCT07120542

Sohag University500 enrolled

Overview

The goal of this study is to understand how menopause affects skin aging in Egyptian women between the ages of 40 and 60. The main question the study wants to answer is: Does menopause cause any changes in how the skin ages? To find out, the participants will be divided into two groups based on their menstrual history: * Women who have not yet gone through menopause (premenopausal) * Women who have already gone through menopause (postmenopausal) A researcher will examine the skin of women in both groups to look for signs of aging. Then, the results will be compared to see if there are any differences between the two groups.

Study Type

OBSERVATIONAL

Enrollment

500

Conditions

Skin Aging

Interventions

DermoscopyDEVICE

dermoscopic assessment of skin aging signs

Eligibility

Sex: FEMALEMin age: 40 YearsMax age: 60 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Females aged 40 to 60 years * Egyptian nationality or residency * Ability to provide informed consent * Classified as either: * Premenopausal (still menstruating regularly) * Postmenopausal (no menstruation for ≥12 months) Exclusion Criteria: * Menopausal transition (Perimenopausal women * Menopause induced by hysterectomy * History of hormone therapy in the past 6 months * Active dermatological conditions affecting the face (e.g. eczema, psoriasis) * Use of anti-aging skin treatments (e.g. laser, fillers, retinoids) * Severe chronic illnesses that may affect skin condition

Outcomes

Primary Outcomes

Clinical skin aging severity using Glogau Photoaging Scale

The Glogau Photoaging Scale will be used for evaluation. Facial assessment will be conducted both at rest and during facial animation to observe dynamic changes. Participant will be categorized into 4 types or grades where type 1 is mild skin aging and type 4 is severe skin aging

Time frame: Assessed once at baseline during participant's visit

Dermoscopic skin aging score using the dermoscopic photoaging assessment scale

this scale is used to assess facial skin aging. The face will be divided into four regions: the forehead, right cheek, left cheek, and chin. Each region will be examined for the presence of the following features: yellowish discoloration, yellow papules, white linear areas indicating skin atrophy, lentigines, hypo- or hyperpigmented macules, telangiectasia, actinic keratoses, senile comedones, deep wrinkles, superficial wrinkles, and criss-cross wrinkles. Scoring follows a binary (yes/no) approach, where the presence of a given feature in any of the four regions scores one point, yielding a total possible score ranging from 0 to 44. a higher score means worse outcome.

Time frame: Assessed once at baseline during participant 's visit

Secondary Outcomes

Prevalence of specific clinical and dermoscopic aging features

Time frame: Recorded during clinical and dermoscopic assessment at baseline

Correlation between menopausal status and severity of skin aging

Time frame: Assessed once at baseline during participant's visit based on menopausal history and skin aging scores

Correlation between menopausal duration and skin aging

Time frame: Menopausal duration collected via history at baseline; skin aging assessed at baseline

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.