The goal of this observational study is to learn about the effects of Hyperbaric Oxygen Therapy on healthy individual who suffer from invasive fungal infection caused by severe trauma, who do not respond to conventional treatment. The main question it aims to answer is: Does the treatment aid in eradicating the infection and improve the overall outcome of such patients?
Study Type
OBSERVATIONAL
Enrollment
7
Hyperbaric Oxygen Therapy at increasing pressure to 2.8 ATA for 2 hours sessions. Breaks of 5 every 20 minutes from the oxygen to air to avoid hyperoxia. Continued for the duration of the hospitalization in the ICU on a daily basis.
Shamir Medical Center
Ẕerifin, Israel
Eradication of Fungal Infectious Agent
The time it takes from the start of treatments and until the first negative culture was found.
Time frame: From enrollment, baseline day 1, through study completion, an average of 4-8 weeks
Clinical Status on Discharge- ventilation status
what support is the patient receiving upon discharge in terms of ventilation including invasive or non-invasive ventilation, need for oxygen or room-air
Time frame: From enrollment, baseline day 1, through study completion, an average of 4-8 weeks
clinical status on discharge- kidney function
the patient's kidney function assessed by presence of elevated Creatinine levels at discharge (mg\\dl)
Time frame: From enrollment, baseline day 1, through study completion, an average of 4-8 weeks
clinical status on discharge- Kidney function
The patient's kidney function assessed by need for dialysis (yes/no)
Time frame: From enrollment, baseline day 1, through study completion, an average of 4-8 weeks
clinical status on discharge- consciousness level
evaluation of the patient's consciousness level as either alert and responsive or still requiring sedation
Time frame: From enrollment, baseline day 1, through study completion, an average of 4-8 weeks
clinical status on discharge- wound status
Whether the patient recieved a successful skin graft
Time frame: From enrollment, baseline day 1, through study completion, an average of 4-8 weeks
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clinical status on discharge- location of discharge
where were the patients discharged to- regular inpatient ward, a different medical center and which department (ICU or regular inpatient), rehabilitation center or not discharged (in case of death during the hospitalization).
Time frame: From enrollment, baseline day 1, through study completion, an average of 4-8 weeks
Adverse Events
description of comlications occuring during the treatment, most notably seizures during the hyperbaric oxygen treatments
Time frame: From enrollment, baseline day 1, through study completion, an average of 4-8 weeks