Effect of Different NanoScaffolds on Pulp Regeneration in Non-Vital Immature Permanent Teeth (Randomized Clinical Trial)

N/AActive Not RecruitingNCT07121348

Tanta University40 enrolled

Overview

the clinical trial aims to evaluate efficency of different scaffolds in cases of regeneration

The aim of this study is to evaluate the clinical and radiographic outcome of regenerative endodontic procedures in immature non-vital permanent teeth using different nanoscaffolds (Platelet-rich fibrin, Mesoporous silica nanoparticles, Hyaluronic acid nanoparticles, Pomegranate nanoparticles)

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Enrollment

Conditions

Necrotic Immature Permanent Incisors

Interventions

Platelet rich fibrinPROCEDURE

platelet rich fibrin is obtained by removing the middle layer from a centrifuged blood sample and is rich with platelets that plays an important role in tissue regeneration mesoporous silica nanoparticles are high surface area and excellent biocompatibility and enhance the outcome hyalurnic acid nanoparticles are high water capacity and involved in cell proliferation and adhesion and help in tissue regeneration pomegranate nanoparticles has anti-inflammatory and antibacterial effect and also help in tissue proliferation and regeneration

Eligibility

Sex: ALLMin age: 9 YearsMax age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria:• Patients free from any systemic diseases that may interfer with the normal healing process. * Maxillary traumatized or cariously exposed non-vital immature anterior teeth. * Teeth don't need for post and core as a final restoration. * Radiographic evidence of an apical opening width more than 2 mm with or without periapical radiolucency. * Teeth without anatomical variations Exclusion Criteria:• Immunocompromised patients * Teeth with previous endodontic treatment. * Teeth with internal or external resorption * Radiographic evidence of root fracture. * Lack of patient and parent cooperation. * Presence of periodontal pocket depth more than 4 mm.

Locations (1)

Faculty of Dentistry,Tanta University

Tanta, Gharbia Governorate, Egypt

Outcomes

Primary Outcomes

apical closure assessed radiographically

radiographic evaluation of apical closure as reduction or elimination of the apical opening of the root

Time frame: 12 months after treatment

Data from ClinicalTrials.gov

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