Early Treatment ctDNA Dynamics to Predict Response to Chemotherapy

Inclusion Criteria: Prior/Concurrent Therapy Criteria 1. Patients must be initiating a new treatment regimen for pancreatic cancer at the time of their initiation in the study 2. Patients must have cytologic or histologic confirmation of pancreatic cancer 3. Patients must have measurable radiographic evidence of metastatic disease 4. Patients must be ≥18 years of age 5. Patients must have an ECOG Performance Status 0-2. 6. Patients must have adequate organ function for delivery of chemotherapy as evidenced by the following: Hgb ≥8 g/dL, platelets ≥ 75 7. Patients must not have renal dysfunction that would prevent administration of IV contrast for radiographic assessment. Regulatory Criteria 8. Patients must be informed of the investigational nature of this study and must sign and give written informed consent for this protocol in accordance with institutional and federal guidelines. 9. Patients of all races, genders, \& ethnicities are eligible. Exclusion Criteria: No exclusion criteria.