The overarching aim of this research is to study the effects of caloric content and timing of meals on measures of postprandial metabolism and cardiovascular response 1. Determine the effect of caloric content on measures of postprandial metabolic flexibility and pulse wave analysis to a mixed meal challenge. 2. Determine the effect of meal timing on measures of postprandial metabolic flexibility and pulse wave analysis to a mixed meal challenge. Hypothesis: 1) that hypercaloric meals will result in significantly reduced indices of metabolic flexibility and pulse wave analysis as compared to eucaloric meals and 2) eucaloric meals consumed later in the day will result in significantly reduced metabolic flexibility and pulse wave analysis as compared to eucaloric meals consumed in the morning.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Enrollment
20
Liquid flavored Ensure Plus Shake of varying caloric content based on individual daily estimated caloric need
George Washington University School of Public Health
Washington D.C., District of Columbia, United States
Pulse Wave Analysis
Augmentation Index normalized to 75 beats per minute as index of pulse wave reflection
Time frame: Baseline to 60 and 120 minutes postprandial
Postprandial Substrate Oxidation
Respiratory Exchange Ratio
Time frame: Baseline to 120 minutes postprandial
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