Serum 25-Hydroxyvitamin D and Neurological Disability in Multiple Sclerosis

University of Zintan369 enrolled

Overview

Vitamin D is hypothesized to play a role in the immunopathology and progression of multiple sclerosis (MS), yet its association with neurological disability remains uncertain, particularly in North African populations.We conducted a cross-sectional study involving 369 adult MS patients across two tertiary neurology centers in Western Libya. Serum 25-hydroxyvitamin D \[25(OH)D\] levels and Expanded Disability Status Scale (EDSS) scores were collected. Pearson correlation, ANOVA, and multivariable linear regression were used to assess associations between vitamin D and disability, adjusting for age, BMI, disease duration, and physical activity. Missing data and outliers were handled systematically using validated R and Python workflows.

Study Type

OBSERVATIONAL

Enrollment

369

Conditions

Multiple Sclerosis

Eligibility

Sex: ALLMin age: 18 YearsMax age: 70 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Libyan nationals. * aged 18 years or older. * diagnosis of MS based on the 2017 revised McDonald criteria. * capable of providing informed consent. * had complete clinical, demographic, and biochemical data. Exclusion Criteria: * presence of other neurological disorders that could mimic MS (e.g., neuromyelitis optica spectrum disorder or Lyme disease). * missing or incomplete medical records. * pregnancy or lactation. * extreme psychiatric or cognitive impairment.

Locations (1)

Outcomes

Primary Outcomes

EDSS

interaction between levels of Vit D and EDSS

Time frame: 24 months

Serum 25-Hydroxyvitamin D

levels of Vit D

Time frame: 24 months