Comparison of the Postoperative Analgesic Effects of ITM and Bi-level ESPB in Liver Transplantation Donors

Ankara Etlik City Hospital60 enrolled

Overview

Liver transplantation is a life-saving procedure for patients with end-stage liver disease, and postoperative pain management is critical for optimizing donor recovery and overall outcomes. Poorly controlled pain following donor hepatectomy may reduce quality of life, delay mobilization, and contribute to the development of chronic pain syndromes. Regional anesthesia techniques, such as intrathecal morphine and erector spinae plane block, have been utilized to enhance postoperative analgesia and reduce perioperative opioid requirements, potentially minimizing opioid-related adverse effects. In this study, we aimed to compare the postoperative analgesic efficacy of intrathecal morphine and Bi-level erector spinae plane block in living liver donors.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

Conditions

Liver Transplantation Pain Management

Interventions

Bi-level Erector Spinae Plane BlockPROCEDURE

Bi-level erector spinae plane block will be performed on the patients using a total of 40 ml of 0.25% bupivacaine under ultrasound guidance. Additionally, in the postoperative period a dexketoprofen dose of 50 mg twice daily were administered iv for multimodal analgesia.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 65 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients aged 18-65 years * American Society of Anesthesiologists (ASA) score I-II * Body Mass Index (BMI) between 18-30 kg/m2 Exclusion Criteria: * Patients under 18 and over 65 years of age * ASA score III and above * Patients with a history of bleeding diathesis * BMI below 18 or above 30 kg/m2

Outcomes

Primary Outcomes

Pain Scores

Pain will be assessed at rest and while coughing using the visual analog scale on a scale from 0 (no pain) to 10 (worst pain). Pain assessment will be done at 0st, 1st, 2nd,4th, 12th, and 24th hours after surgery.

Time frame: On the operation day

Secondary Outcomes

Intraoperative opioid consumption

Remifentanil consumption for intraoperative period will be recorded

Time frame: Intraoperative period

Postoperative Opioid Consumption

Opioid consumption for 24 hours will be recorded