Observational Study With Additional Procedures: Metabolomic and Ultrastructural Findings of Allograft in Heart Transplantation and Their Correlation With Graft Dysfunction.

Left ventricular dysfunction (longitudinal global strain (LGS) < -14% at 1 month and <-17% at 6 and 12 months and/or FEvsx <50%) at 1, 6, 12 months after transplant (in absence of rejection)

Time frame: At 1, 6, 12 months after transplant

Left ventricular failure (LV EF <40%) within 24 hours post transplantation

Time frame: Within 24 hours post transplantation

Right ventricular failure (TAPSE <16% and/or FAC < 35% and/or S' wave velocity < 10 cm/sec) within 24 hours post transplantation

Time frame: Within 24 hours post transplantation

Hemodynamic: Cardiac Index < 2 L/min/mq, wedge pressure >20 mmHg, right atrial pressure (RAP > 15 mmHg) within 24 hours post transplantation and at 1, 6, 12 months after transplant (in absence of rejection)

Time frame: At 1, 6, 12 months after transplant

Death for graft failure within 24 hours post transplantation

Time frame: Within 24 hours post transplantation

ECMO within 24 hours of transplant for ventricular failure

Time frame: Within 24 hours of transplant

IABP within 24 hours of transplant for ventricular failure

Time frame: Within 24 hours of transplant

Echocardiographic parameters: E/A>>1; DT<150 msec; E/e'>15, atrial strain at 1, 6, 12 months after transplant (in absence of rejection)

Time frame: At 1, 6, 12 months after transplant

Death at 1, 6, 12 months after transplant (in absence of rejection

Time frame: At 1, 6, 12 months after transplant

Trend of cardiac biomarker (BNP), trend of TNIhs, angiotensinogen, ADIPOQ, HGFAC, IGFBP3, other markers of ischaemia

Time frame: At first and third week