This study was designed to evaluate the impact of a 16-week yoga program on BMD, bone metabolism markers, and physical fitness in elderly patients with OP.
To assess the effects of a 16-week yoga intervention on bone mineral density (BMD), bone metabolism, and physical fitness in elderly patients with osteoporosis. This randomized controlled trial enrolled 60 adults aged 50 years or older with clinically confirmed osteoporosis. Based on personal preference, participants were assigned to either a yoga group or a control group. The intervention consisted of supervised yoga sessions conducted twice weekly for 16 weeks. The yoga intervention included physical postures, breathing exercises, and meditation/relaxation techniques. Health outcomes were assessed at baseline, mid-intervention (8 weeks), and post-intervention (16 weeks). Primary outcomes included changes in BMD at the lumbar spine and hips. Secondary outcomes comprised serum levels of osteocalcin, procollagen type 1 N-terminal propeptide (P1NP), β-CTX, 25-hydroxyvitamin D, calcium, phosphate, and performance in physical function tests, including grip strength, chair stand, single-leg balance, and timed up-and-go. This randomized controlled trial aims to find out the effect of yoga intervention on bone mineral density (BMD), bone metabolism, and physical fitness in elderly patients with osteoporosis.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
60
: Participants in this arm received a structured yoga course intervention for a period of 4 months. Sessions were held twice weekly, with each lasting 60 minutes. The curriculum was specifically designed to be gentle, slow-paced, and low-impact, making it suitable for older adults while emphasizing body awareness, mind-body integration, and psychological regulation. The course content included: breathing exercises (e.g., basic abdominal breathing combined with simple movements), asana (posture) practice (e.g., seated chair exercises, standing poses, prone poses, supine poses, and side-lying poses, emphasizing muscle activation, joint flexibility, bodybalance training, and coordination of breath with movement), and meditation and relaxation (e.g.supine rest, moon breath training, and OM chanting). All classes were instructed by experienced yoga teachers certified by the Yoga Alliance.
Beijing Sport University
Beijing, Beijing Municipality, China
bone mineral density
assessed by dual-energy X-ray absorptiometry (DXA, HOLOGIC Discovery Wi, Bedford, MA, USA), at lumbar spine and bilateral hips. Osteoporosis was diagnosed according to the World Health Organization criteria based on T-scores.
Time frame: baseline and 4 month
N-MID Osteocalcin
N-MID osteocalcin is an important biomarker of bone metabolism, mainly reflecting bone formation activity. It is commonly used in clinical practice to evaluate the efficacy of osteoporosis, bone turnover abnormalities, and anti bone resorption therapy
Time frame: baseline and 4 month
Procollagen 1 N-terminal Propeptide
Procollagen I N-terminal propeptide (P1NP) is a biomarker that plays an important role in bone metabolism
Time frame: baseline and 4 month
β-terminal telopeptide of I collagen (β-CTx)
β-terminal telopeptide of I collagen (β-CTx) has been reported to be a sensitive biochemical marker of bone turnover
Time frame: baseline and 4 month
25-hydroxyvitamin D
25 hydroxyvitamin D (25-OH VitD) is the main storage form of vitamin D in the human body and a core indicator for evaluating the nutritional status of vitamin D. It maintains bone health by regulating calcium and phosphorus metabolism
Time frame: baseline and 4 month
Lower Limb Major Muscle Group Strength (Quadriceps Femoris, HamstringsTriceps Surae, Tibialis Anterior, lliopsoas)
Assesses the strength of major lower limb muscle groups, including the quadricepsfemoris, hamstrings, triceps surae, tibialis anterior, and iliopsoas. Maximum isometric contraction values for both sides are recorded using a MlCROFET2 standardized electronic dynamometer to comprehensively reflect individual lower limb support and gait stability.
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Time frame: Baseline, 2 Months Post-ntervention, and 4 Months Post-Intervention