This is a single-center, parallel-arm, 4-week interventional study designed to evaluate the lifting and firming efficacy of two facial care regimens in middle-aged Chinese women. Participants were randomly assigned to use either a retinol-based day cream or a lotion-and-toner bundle. The study included dermatologist assessment, standardized facial photography, and self-assessment questionnaires. A total of 132 healthy women aged 45-55 with facial skin sagging were enrolled. The primary objective was to compare improvement in lifting grades after 4 weeks of product use. The trial was conducted at China-Norm Quality Technical Service Co., Ltd., in Shanghai, China.
This 4-week study evaluated the efficacy of two skincare regimens on facial lifting and firmness in middle-aged Chinese women. Participants were randomly assigned to one of two arms: (1) retinol-based day cream or (2) a bundle of toner and lotion. The study included a 3-week wash-out period, followed by a 4-week treatment phase with full-face application. Assessments were conducted at T0 (baseline), Timm (immediate post-use), and T4w (end of 4-week use), using dermatologist grading (0-9 scale), DEEP imaging system, and self-reported questionnaires. Participants were required to avoid other skincare products during the study. A total of 132 subjects were enrolled; at least 80 completed clinical evaluation. The primary outcome was improvement in lifting grade from T0 to T4w; secondary outcomes included imaging analysis and subjective satisfaction. The study followed GCP principles and received ethical approval from the Ethics Committee at China-Norm. No serious adverse events were reported.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
132
A commercially available day cream containing retinol and moisturizing ingredients. Applied twice daily (morning and evening) to the full face for 4 weeks.
A skincare regimen including a dermalift toner and a milky lotion. Applied twice daily (morning and evening) to the full face for 4 weeks.
Shanghai China-norm Quality Technical Service Co., Ltd., Shanghai, Shanghai 200072
Shanghai, China
Clinical Assessment by Dermatologist
Lifting grade (0-9 scale) will be evaluated by dermatologist at T-3w, T0 (baseline), Timm and T4w.Six areas will be evaluated separately: eyebrow, upper eyelid, nasolabial zone, apple cheek, corner of mouth and jaw.
Time frame: Baseline and Week 4
Change in Facial Wrinkle Depth Measured by Standardized Digital Photography and Image Analysis Software
Time frame: Baseline and Week 4
Questionnaire
Change in self-reported score for skin smoothness and softness from baseline to week 4, based on 5-point Likert scale questionnaire
Time frame: Baseline and Week 4
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