Correlations of the Microvascular Abnormalities on NVC (Nail Fold Video Capillaroscopy) and GAVE (Gastric Antral Vascular Ectasia) as Seen on EGD

N/AEnrolling By InvitationNCT07127952

Mayo Clinic75 enrolled

Overview

The purpose of this research is to determine whether a procedure called capillaroscopy can help distinguish patients who are diagnosed with GAVE (gastric antral vascular ectasia) with an autoimmune disease versus idiopathic/other conditions based on EGD findings.

The primary aim of this study is to define the prevalence and findings (as per quantification) of nail fold video capillaroscopy abnormalities in patients with GAVE. The secondary aim is to compare the findings of NVC and clinical presentation in patients with GAVE.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

SUPPORTIVE_CARE

Masking

NONE

Enrollment

Conditions

Gastric Antral Vascular Ectasia

Interventions

Video CapillaroscopyDEVICE

A non-invasive imaging technique used to assess capillary structure and morphology in the nailfold area, commonly used in evaluating microvascular changes associated with connective tissue diseases.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 95 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients 18 years and older with gave diagnosis as pair EGD performed in Gastroenterology as standard of care. Patients with GAVE with connective tissue disease will be compared to patients with GAVE without a connective tissue disease. Exclusion Criteria: * Age less than 18 years of age, pregnant individuals, dialysis dependent, type 2 diabetes, recent hand trauma or manicure (\<2 weeks), routine use of vibratory tools, history of acrocyanosis or erythromelalgia, previous diagnosis of a bleeding disorder, diagnosis of psoriasis, diagnosis of anti-phospholipid syndrome, exposure to toluene or benzoyl, diagnosis of psoriasis, diagnosis of COPD.

Locations (3)

Mayo Clinic (Florida)

Jacksonville, Florida, United States

Mayo Clinic Health System-Eau Claire Clinic

Eau Claire, Wisconsin, United States

Mayo Clinic Health Systems

Eau Claire, Wisconsin, United States

Outcomes

Primary Outcomes

Prevalence and Phenotypic with G.A.V.E

Defined the prevalence and phenotype of nail fold video capillaroscopy abnormalities in patients with G.A.V.E.

Time frame: From enrollment to end of study once the accrual has been met within baseline of Day 1

Secondary Outcomes

Comparing Findings

To compare the findings of and VC and clinical manifestation and organ involvement patients with gave and connective tissue disease to those with gave without connective tissue disease.

Time frame: From enrollment to end of study once the accrual has been met within baseline of day 1

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.