Study Effects of Preoperative Modafinil on Recovery Profile of Morbidly Obese Patients Scheduled for Bariatric Surgery if it Can Enhance Recovery From Anesthesia

Ain Shams University20 enrolled

Overview

study Effects of Preoperative Modafinil on Recovery Profile of Morbidly Obese Patients Scheduled for Bariatric Surgery if it Can Enhance Recovery From Anesthesia and provide improvement in recovery

The study was conducted to 20 patients scheduled for bariatric surgeries. The study group (Modafinil group) received oral 200 mg modafinil 8 hours before surgery and then another 200 mg 2 hours before surgery. The other group (Placebo group) were given placebo through the same regimen as Modafinil. Immediate recovery time, cognitive recovery, emotional (general) status, discharge from PACU according to modified Aldrete score were assessed.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

DOUBLE

Enrollment

Conditions

Obese Adolescents Bariatric Surgery

Interventions

ModafinilDRUG

dose of modafinil preoperatively for for active comparator

Eligibility

Sex: ALLMin age: 18 YearsMax age: 60 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: 1. Patients aged from 18 to 60 years. 2. Patients ASA II or III undergoing elective bariatric surgery. 3. BMI 30-50 kg/m2. Exclusion Criteria: 1. Patient's refusal. 2. Age below 18 or above 60y. 3. History of cardiac disease. 4. History or known allergy to Modafinil. 5. Underlying liver or renal failure. 6. Chronic neurological or psychiatric condition. 7. Hemodynamically unstable patients. 8. History of drug dependance. 9. Habitual coffee consumption exceeding 2 cups per day.

Locations (1)

Ain Shams University

Cairo, Egypt

Outcomes

Primary Outcomes

both groups were assessed as regard incidence of enhancement of immediate and cognitive recovery Comparison between groups as regard words recall as part of cognitive recovery data.

Groups were compared in the primary outcome of our work (immediate recovery data) in OR by time intervals (T1, T2, T3 and T4) Comparison between groups as regard orientation as part of cognitive recovery score

Time frame: 1 day

Secondary Outcomes

assessment of difference of general and emotional status between both patients groups postoperatively

Groups were compared in assessment of general status and emotion and assessment of modified Aldrete score in PACU and compare between both groups

Time frame: 24 hours

Data from ClinicalTrials.gov

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