Assesment of Treatment Outcomes of Aquired Aplastic Anemia in Children : A Retrospective and Prospective Cohort

Inclusion Criteria: * Children aged 1-18 years diagnosed with acquired aplastic anemia, as confirmed by bone marrow examination and fulfilling diagnostic criteria (e.g., bone marrow cellularity \<25% and at least two of the following: absolute neutrophil count \<500/μL, platelet count \<20,000/μL, absolute reticulocyte count \<60,000/μL)123. * The bone marrow biopsy should be compitable with diagnosis * Diagnosed and/or treated at Assiut University Children's Hospital between Agust 2023 and Augst 2026. * Patients with complete medical records, including diagnostic, laboratory, and treatment data Exclusion Criteria: * Patients with inherited bone marrow failure syndromes (e.g., Fanconi anemia, dyskeratosis congenita) as confirmed by genetic testing or family history21. * Patients with incomplete or missing essential data in their medical records. * Patients diagnosed outside the specified study period or managed primarily at other institutions. * Patinets with neoplastic or granulomatous disease involving the bone marrow, systemic lupus erythematosus, AIDS, hypersplenism or other conditions associated with pancytopenia such as myelodysplastic syndrome,and paroxysmal nocturnal hemoglobinuria. * Patients exposed to antineoplastic chemotherapy or radiotherapy were excluded