This prospective, open-label, randomized controlled trial aims to evaluate the efficacy of intravenous amino acid infusion in reducing AKI after LDLT. Eligible adult patients undergoing LDLT will be randomized into two groups: one receiving Continuous infusion of a L-amino acids mixture in a dose of 2 g/kg dry body weight/day (to a maximum 100 g/day) after induction of anesthesia and insertion of CVP line till 72 hours after treatment initiation, and the other receiving standard management. The primary outcome is the incidence of AKI as per KDIGO criteria within 7 days of transplant.
This prospective, open-label, randomized controlled trial aims to evaluate the efficacy of intravenous amino acid infusion in reducing AKI after LDLT. Eligible adult patients undergoing LDLT will be randomized into two groups: one receiving Continuous infusion of a L-amino acids mixture in a dose of 2 g/kg dry body weight/day (to a maximum 100 g/day) after induction of anesthesia and insertion of CVP line till 72 hours after treatment initiation, and the other receiving standard management. The primary outcome is the incidence of AKI as per KDIGO criteria within 7 days of transplant.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
NONE
Enrollment
100
Continuous infusion of a L-amino acids mixture in a dose of 2 g/kg dry body weight/day (to a maximum 100 g/day) after induction of anesthesia and insertion of CVP line till 72 hours after treatment initiation
Standard peri tranplant care as per out institution including intra operative and post operative care. Its includes starting of immunosuppression after serial blood investigation monitoring.
Ilbs Hospital, D1 Vasant Kunj, New Delhi
New Delhi, National Capital Territory of Delhi, India
To compare the incidence of early post transplant AKI
To compare the incidence of early post transplant AKI (within 1st week) in patients undergoing LDLT between L-amino acids infusion and standard treatment groups
Time frame: Within 7 days post transplant
To Determine the severity of early post Liver transplant AKI
To Determine the severity of early post Liver transplant AKI
Time frame: 7 days
To determine eGFR at Day 30 and 90.
To determine eGFR at Day 30 and 90.
Time frame: 90 days
The use and duration of kidney-replacement therapy during the hospital stay The use and duration of kidney-replacement therapy during the hospital stay
The use and duration of kidney-replacement therapy during the hospital stay The use and duration of kidney-replacement therapy during the hospital stay
Time frame: 1 month
The duration of mechanical ventilation, ICU stay and in hospital stay.
The duration of mechanical ventilation, ICU stay and in hospital stay.
Time frame: 1 month
In Hospital Mortality
In Hospital Mortality
Time frame: 1 month
Major Morbidity (Clavien-Dindo ≥3) and Early Graft Dysfunction.
Major Morbidity (Clavien-Dindo ≥3) and Early Graft Dysfunction.
Time frame: 1 month
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