Study of Efficacy and Safety of Cream Infused With HuangQin (Root of Scutellaria Baicalensis) Extract for the Reduction of Hyperpigmentation

Mae Fah Luang University38 enrolled

Overview

The aim of this study is to evaluate the efficacy of a topical cream infused with Scutellaria baicalensis extract in reducing hyperpigmentation on the face. The study is experimental clinical pilot study as a single group pretest-posttest. A ROAT is conducted 1 week prior to the experiment. Participant apply the cream on the hypigmented area daily. Facial skin parameters (i.e. melanin index, erythema index) is evaluated at week 0, 1, 2 and 4.

Study Type

INTERVENTIONAL

Allocation

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Hyperpigmentation; Melanin

Interventions

Investigator developed cream infused with HuangQin extractOTHER

A water in oil emulsion with consistency similar to cold cream. Infused with organic extract of scutellaria baicalensis.

Eligibility

Sex: ALLMin age: 30 YearsMax age: 60 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Male or Female * Has at least 1 hyperpigmentation spot (size \> 3mm) on either side of the face * 30-60 y/o * Fitzpatrick skin types II-IV * Agrees to use sunscreen SPF50+ and willing to avoid strong sunlight exposure during the study Exclusion Criteria: * Pregnant or lactating * Use of whitening products or treatment within 1 month before this study * Currently using contraceptives * History of allergy to any ingredient in the intervention cream * Has skin conditions which can interfere with the measurement (i.e. severe acne, eczema, herpes simplex) * Severe disease (i.e. immunodeficiency, cancer) * Enrolled in other clinical study within 3 month before this study

Locations (1)

Mae Fah Luang University

Muang, Changwat Chiang Rai, Thailand

Outcomes

Primary Outcomes

Efficacy of hyperpigmentation reduction property of the intervention

Measured the melanin index of the hyperpigmented area

Time frame: Week 0, 1, 2 and 4

Safefty profile of the intervention

Record and collect the adverse effect from the usage of the interventional cream

Time frame: Week 1, 2 and 4

Secondary Outcomes

Efficacy of erythema reduction property of the intervention

Measured the erythema index of the hyperpigmented area

Time frame: Week 0, 1, 2 and 4

Efficacy of skin hydration property of the intervention

Measured the skin hydration value of the hyperpigmented area

Time frame: Week 0, 1, 2 and 4

Data from ClinicalTrials.gov

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