Combination of Mixed Drugs vs Ibuprofen: a Randomized Clinical Trial

Universidad Complutense de Madrid12 enrolled

Overview

Combination of vitamins and melatonine compared with the conventional use of ibuprofen after surgical third molar extraction

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

TRIPLE

Enrollment

Conditions

Swelling Lips &Amp; Face Pain Trismus

Interventions

Third molar extractionPROCEDURE

Surgical third molar extraction with conventional medication

Eligibility

Sex: ALLMin age: 18 YearsMax age: 35 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Healthy volunteers, non ibuprofen allergic, presence of impacted lower third molar Exclusion Criteria: * Diseases that avoid surgical intervention

Locations (1)

Complutense University of Madrid

Madrid, Spain

Outcomes

Primary Outcomes

Post operative pain

VAS pain scale

Time frame: 10 DAYS

Swelling

Face measurement for swelling

Time frame: 7 DAYS

Trismus

Opening limitation

Time frame: 7 DAYS

Secondary Outcomes

Rescue analgesia

Need for more medications

Time frame: 7 DAYS

Inflammatory profile

Blood cytokines

Time frame: 7 days

Data from ClinicalTrials.gov

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