Noninvasive ventilation (NIV) has revolutionized the management of patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) with hypercapnic respiratory failure (HcRF). NIV use has been shown to reduce the need for endotracheal intubation, hospital and intensive care unit (ICU) length of stay, and mortality. Multiple studies have been conducted on weaning strategies among patients requiring invasive mechanical ventilation. As a result of these studies, definite criteria and protocols have been laid down for weaning from invasive mechanical ventilation. However, no such data are available for the withdrawal of NIV. Evidence-based reviews suggest that protocols to manage the weaning and liberation of subjects from Mechanical Ventilation could reduce the time that subjects spend receiving mechanical ventilation. However, no such data about protocolized withdrawal of NIV are available.
A study to compare protocolized weaning from non-invasive ventilation using three potential strategies of weaning from NIV * Stepwise reduction of duration of NIV use, * Stepwise reduction in pressure support of NIV, and * Immediate withdrawal of NIV. Among patients with Acute respiratory failure due to acute exacerbation of COPD.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
60
Weaning from noninvasive ventilation for patients with acute exacerbation of COPD
Assiut University hospital
Asyut, Egypt
Successful weaning
The primary objective of the study is to compare the rate of successful withdrawal of NIV among the three groups.
Time frame: 48 hours
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.