Phrenic Nerve Stimulation for Reducing Ventilation Duration in Acute Cerebral Infarction: A Multicenter Randomized Controlled Trial

Inclusion Criteria: * age ≥ 18 years old * no gender restrictions * patient diagnosed with acute cerebral infarction (within 30 days of onset) through cranial CT or MRI * duration of mechanical ventilation ≥ 24 hours * patient or their legal guardian agrees to participate in the study and signs an informed consent form Exclusion Criteria: * there are other significant conditions that affect diaphragm function, such as severe malnutrition, irreversible respiratory pump failure caused by medullary or cervical cord injury, and irreversible damage to the phrenic nerve * significant agitation cannot be combined with transcutaneous electrical phrenic nerve stimulation * severe skin damage or infection at the electrode placement site * previous presence of severe lung disease (such as severe COPD, interstitial lung disease, pulmonary embolism, etc.), severe heart failure (NYHA Class IV) * sepsis or shock requiring high-dose vasopressors * the terminal state of the disease or expected survival period does not exceed 7 days * pacemaker implantation * pregnant or lactating women * patients whose family members express their willingness to withdraw for treatment