Postoperative Opioid Consumption in Gastric Sleeve Surgery

Balikesir University96 enrolled

Overview

The study aimed to compare balanced anesthesia protocols using only opioids as analgesics during induction in gastric sleeve surgery with protocols using opioids and ketamine together in terms of anesthesia management, opioid side effects, and postoperative analgesia.

During gastric sleeve surgery under general anesthesia, various drugs are administered intraoperatively to induce loss of consciousness, immobility, and pain relief (analgesia). Opioids are the most commonly used analgesics. However, the response to opioids varies widely, and their use is associated with significant side effects. In balanced general anesthesia, in addition to opioid medications, hypnotics, NMDA antagonists (ketamine, magnesium sulfate), sodium channel blockers (local anesthetics), anti-inflammatory drugs (NSAIDs, dexamethasone), and alpha-2 agonists (dexmedetomidine, clonidine) may be used. One of the components of ERAS (Enhanced Recovery After Surgery) protocols, which aim to reduce metabolic stress developing in response to surgery and promote rapid recovery after surgery, is to provide effective postoperative analgesia while using opioids as little as possible. These different anesthesia approaches may offer options for surgery. The addition of ketamine to anesthesia induction and maintenance may affect postoperative opioid consumption. Adding ketamine to anesthesia induction and maintenance may affect postoperative opioid consumption. Reducing opioid consumption can prevent opioid-related side effects such as nausea, constipation, and itching. Opioid-related side effects such as nausea, constipation, and itching can be prevented by reducing opioid consumption.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Obesity &Amp; Overweight General Anesthetic Ketamine

Eligibility

Sex: ALLMin age: 18 YearsMax age: 65 Years

Medical Language ↔ Plain English

Inclusion Criteria: Patients who have undergone gastric sleeve surgery Patients with mild systemic disease Patients with severe systemic disease that does not affect daily activities Exclusion Criteria: Those with data loss in their files Those who do not use patient-controlled analgesia devices Patients who did not undergo standard anesthesia protocol

Locations (1)

Balıkesir University Health Practice and Research Hospital

Balıkesir, Turkey (Türkiye)

Outcomes

Primary Outcomes

Morphine Equivalent Opioid Consumption

A comparison was made based on the equivalent doses of opioid analgesic drugs used in both groups relative to morphine.

Time frame: 24 hours

Secondary Outcomes

Postoperative Pain

Postoperative pain is assessed using a numerical pain scale. The Numerical Pain Rating Scale (NRS) was used in the study. NRS pain scores range from 0 (no pain) to 10 (most severe pain)

Time frame: 24 hours

Data from ClinicalTrials.gov

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