A Study of Genetic Influence on LDL Hyper-responsiveness in Patients Following a Ketogenic Diet

Mayo Clinic100 enrolled

Overview

The purpose of this study is to identify whether individuals following a ketogenic diet who experience extreme LDL-C elevation, termed "hyper-responders", have identifiable genetic variations in genes involved in cholesterol absorption.

Study Type

OBSERVATIONAL

Enrollment

100

Conditions

LDL Hyper-responsiveness

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * 18 years of age or older * LDL-C \>170 mg/dL in response to starting a ketogenic diet Exclusion Criteria: * Patients who do not consent to blood draw for genetic testing * Those with LDL-C \<170 mg/dL on a ketogenic diet

Locations (1)

Mayo Clinic

Rochester, Minnesota, United States

RECRUITING

Outcomes

Primary Outcomes

Number of Patients to have a genetic mutation

Genetic Mutation will be defined as a mutation in ABCG5, ABCG8, APOB, APOE, CETP, CYP27A1, LDLR, LDLRAP1, LIPA, LPL, LRP6, and PCSK9 genes

Time frame: Baseline

Central Contacts

Saad Omar

CONTACT

507-538-5162 omar.saad@mayo.edu

Data from ClinicalTrials.gov

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