This study will investigate whether mentally simulating walking movements while watching others walk can improve walking performance in individuals with Multiple Sclerosis (MS). Participants will be divided into two groups: one group will watch walking videos and imagine themselves walking, while the other group will watch nature scenes. The study will measure muscle activity and walking patterns to assess the effects. The results may help support the use of mental practice techniques to improve mobility in people with MS.
This study aims to explore the impact of mental simulation of walking movements on walking performance in individuals with Multiple Sclerosis (MS). The participants will be randomly assigned to two groups: the experimental group will watch walking-related videos and engage in mental imagery exercises, imagining themselves walking, while the control group will watch nature scenes without any walking-related content. Objectives: To determine whether mental imagery can enhance walking ability and gait parameters in individuals with MS. To measure the effect of mental simulation on muscle activity and walking patterns, including stride length, walking speed, and balance. Study Procedure: The study will consist of multiple sessions, where participants will first undergo baseline assessments of walking ability. Following this, they will engage in either the walking video and imagery task (experimental group) or the nature video viewing task (control group) for a predetermined period of time. Measurements of muscle activity using electromyography (EMG) and walking patterns will be recorded before and after the intervention. Potential Impact: The results from this study may provide insights into the use of mental practice techniques as a non-invasive intervention to improve mobility in individuals with MS, a population often affected by walking difficulties. Mental imagery could serve as an adjunct therapy to traditional physical rehabilitation methods.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
SUPPORTIVE_CARE
Masking
SINGLE
Participants will watch videos showing walking actions and will be instructed to mentally simulate the movement.
Participants will watch a video of nature scenes.
Hacettepe University, Faculty of Physical Therapy and Rehabilitation
Ankara, Turkey (Türkiye)
RECRUITINGChange in Tibialis Anterior and Gastrocnemius Medialis Muscle Activity Amplitude
Change in muscle activity amplitude (microvolts, µV) of tibialis anterior and gastrocnemius medialis during gait initiation measured by surface EMG.
Time frame: Before and immediately after the intervention
Change in Tibialis Anterior and Gastrocnemius Medialis Muscle Activity Onset Latency
Change in onset latency (milliseconds, ms) of tibialis anterior and gastrocnemius medialis muscle activation during gait initiation measured by surface EMG.
Time frame: Before and immediately after the intervention.
Change in Step Length
Change in step length (centimeters, cm) during gait initiation measured by the GAITRite system.
Time frame: Before and immediately after the intervention
Change in Step Time
Change in step time (seconds, s) during gait initiation measured by the GAITRite system.
Time frame: Before and immediately after the intervention
Change in Step Width
Change in step width (centimeters, cm) during gait initiation measured by the GAITRite system.
Time frame: Before and immediately after the intervention
Change in Double Support Period
Change in double support period (percentage of gait cycle, %) during gait initiation measured by the GAITRite system.
Time frame: Before and immediately after the intervention
Change in Gait Velocity
Change in gait velocity (centimeters per second, cm/s) during gait initiation measured by the GAITRite system.
Time frame: Before and immediately after the intervention
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Enrollment
20
Change in Cadence
Change in cadence (steps per minute, steps/min) during gait initiation measured by the GAITRite system.
Time frame: Before and immediately after the intervention
Motor Imagery Vividness
Kinesthetic and visual imagery vividness will be assessed using the Kinesthetic and Visual Imagery Questionnaire-20 (KVIQ-20), which includes 10 visual and 10 kinesthetic items (20 total). Each item is rated on a 5-point Likert scale (1 = no image/sensation, 5 = vivid image/sensation). Higher scores indicate better imagery ability.
Time frame: Baseline only
Mental Chronometry Ratio
The ratio between imagined and actual Timed Up and Go (TUG) performance time (both measured in seconds, s) will be calculated. During imagined trials, participants will press a button to mark the start and end of the imagined movement sequence. A ratio closer to 1 indicates better temporal congruence between imagined (iTUG) and executed TUG performance.
Time frame: Baseline only
Limb Laterality Recognition Performance
Right-left discrimination ability will be evaluated using the Recognise Foot App™ developed by the NOI Group™. Both accuracy (percentage of correct responses, %) and response time (milliseconds, ms) will be recorded.
Time frame: Baseline only
Cognitive Status
General cognitive functioning will be screened using the Standardized Mini-Mental State Examination (SMMSE). The test is scored on a 30-point scale (0-30). Scores ≥24 indicate normal cognitive functioning.
Time frame: Baseline only
Fatigue Level
Fatigue severity specific to MS will be measured with the Fatigue Severity Scale (FSS). The FSS consists of 9 items rated on a 7-point Likert scale (1 = strongly disagree; 7 = strongly agree). The final score is calculated as the mean of all items (range: 1-7), with higher scores indicating greater fatigue severity.
Time frame: Baseline only
Anxiety and Depression
Emotional state will be assessed using the Hospital Anxiety and Depression Scale (HADS). The scale consists of 14 items divided into two subscales: anxiety (7 items) and depression (7 items). Each item is scored from 0 to 3, yielding subscale scores ranging from 0 to 21. Higher scores indicate greater levels of anxiety or depression.
Time frame: Baseline only
Disability Level
Expanded Disability Status Scale (EDSS) scoring will be performed using the standardized Neurostatus-EDSS format. This scale evaluates functional systems such as motor ability, balance, vision, and sensory function to quantify disability level in individuals with multiple sclerosis. Scores range from 0 to 10 in 0.5-point increments, where 0 indicates normal neurological status and 10 represents death due to MS. Higher scores reflect greater disability.
Time frame: Baseline only
Visual Acuity
Participants' visual acuity will be assessed using the Snellen chart under standard conditions. The test will be conducted with or without corrective lenses depending on the participant's usual visual aid usage. Visual acuity will be recorded as a Snellen fraction (e.g., 20/20, 20/40), where larger denominators indicate poorer visual performance.
Time frame: Baseline only